29489-04-1

Usage

Uses

Used in Pharmaceutical Research:
4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE is used as a chemical intermediate for the production of drugs, leveraging its structural features to contribute to the development of new pharmaceutical agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE serves as a reagent, facilitating the creation of complex organic molecules for a range of applications, including the enhancement of drug efficacy and the exploration of novel chemical reactions.
Used in Biological Activity Studies:
Although its biological activities are yet to be fully explored, 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE may also be used as a subject of study in biological research to uncover potential therapeutic effects or mechanisms of action that could be harnessed in medicine.

InChI:InChI=1/C17H16BrNO3S/c1-12-6-8-13(9-7-12)23(21,22)19-11-10-15(18)17(20)14-4-2-3-5-16(14)19/h2-9,15H,10-11H2,1H3

Upstream product

• 24310-36-9 1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 50998-74-8 methyl N-tosylanthranilate 
• 1127-74-8 1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 105895-93-0 methyl 2-{(3-cyanopropyl)[(4-methylphenyl)sulfonyl]amino}benzoate 
• 134-20-3 2-carbomethoxyaniline 
• 68595-19-7 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile 

Downstream Products

• 717917-14-1 2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 
• 195531-22-7 {4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}amine 
• 318237-73-9 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 
• 168626-94-6 conivaptan hydrochloride 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: Formula (I) which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions

Synthetic method of 2-methyl-6-(4-methylphenyl)sulfonyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

The invention provides a synthetic method of 2-methyl-6-(4-methylphenyl)sulfonyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. According to the invention, compound 4-bromo-1-[(4-methylphenyl) sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepine-5-one represented by formula I is reacted with acetamidine hydrochloride in the presence of cesium carbonate in a reaction solvent. The synthetic method comprises following advantages compared with the prior art, reaction temperature is lower, reaction time is shorter, and finished product yield and purity are both increased to certain degrees.

A scalable process for the synthesis of 2-methyl-1,4,5,6- tetrahydroimidazo[4,5-d][1]benzazepine monohydrate and 4-[(biphenyl-2- ylcarbonyl)amino]benzoic acid: Two new key intermediates for the synthesis of the AVP antagonist conivaptan hydrochloride

A process for the multikilogram synthesis of the dual vasopressin-receptor antagonist, conivaptan hydrochloride, has been developed. This method relies on the introduction of operationally simple chemistry during the final stages of the process when two k

A new synthetic route to YM087, an arginine vasopressin antagonist

A new synthesis of N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl} biphenyl-2-carboxamide monohydrochloride (1, YM087) via new imidazobenzazepine intermediates is described. This method remarkably improves the overall yiel