1-Methoxy-4-n-pentylbenzene

Base Information

• Chemical Name: 1-Methoxy-4-n-pentylbenzene
• CAS No.: 20056-58-0
• Molecular Formula: C12H18O
• Molecular Weight: 178.274
• Hs Code.: 2909309090
• Mol file: 20056-58-0.mol

Synonyms:Benzene, 1-methoxy-4-pentyl;1-Methoxy-4-pentylbenzene;p-Pentylanisole;

Chemical Property of 1-Methoxy-4-n-pentylbenzene

Chemical Property:

• Vapor Pressure: 0.0343mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 250.5 °C at 760 mmHg
• Flash Point: 108.1 °C
• PSA: 9.23000
• Density: 0.91 g/cm³
• LogP: 3.42790

Purity/Quality:

98%min ^*data from raw suppliers

1-METHOXY-4-N-PENTYLBENZENE 1.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methoxy-4-n-pentylbenzene

There total 39 articles about 1-Methoxy-4-n-pentylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(4-methoxyphenyl)pentanol (19523-03-6) → 1-(4-Methoxyphenyl)pentane (20056-58-0)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; at 25 ℃; for 1h;

Reference yield: 91.0%

butyl magnesium bromide (693-04-9) + p-methoxybenzyl chloride (824-94-2) → 1-(4-Methoxyphenyl)pentane (20056-58-0)

Guidance literature:

p-methoxybenzyl chloride; With bis(acetylacetonate)nickel(II); Allyl ether; In tetrahydrofuran; at 23 ℃; for 0.0833333h; Sealed tube; Inert atmosphere;

butyl magnesium bromide; In tetrahydrofuran; at 0 ℃; for 0.166667h; Reagent/catalyst; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201403007

Reference yield: 90.0%

1-Bromopentane (110-53-2) + 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonic acid 4-methoxyphenyl ester (93131-74-9) → 1-(4-Methoxyphenyl)pentane (20056-58-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5-(dicyclohexylphosphaneyl)-1-(2,6-diisopropoxyphenyl)-1H-pyrazole; magnesium; lithium chloride; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 24h; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201711990

upstream raw materials:

p-Methoxyvalerophenon

1-hexyl-4-methoxybenzene

1-(4-methoxyphenyl)pentanol

1-methoxy-4-(pent-1-en-1-yl)benzene

Downstream raw materials:

2-cyano-4-n-pentylanisole

2-cyano 4-n-pentylbutylphenol

2-bromo-1-methoxy-4-pentylbenzene

Refernces

• 1、 -. "Aryl or heteroaryl methoxylation reaction method". Paragraph 0155-0161. . Retrieved 2021/11/21.
• 2、 Zhang, Ke-Feng,Christoffel, Fadri,Baudoin, Olivier. "Barbier–Negishi Coupling of Secondary Alkyl Bromides with Aryl and Alkenyl Triflates and Nonaflates". supporting information. p. 1982 - 1986. Retrieved 2018/02/06.