Benzenemethanol, a-butyl-4-methoxy-

Base Information

• Chemical Name: Benzenemethanol, a-butyl-4-methoxy-
• CAS No.: 19523-03-6
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol file: 19523-03-6.mol

Synonyms:

Chemical Property of Benzenemethanol, a-butyl-4-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-butyl-4-methoxy-

There total 19 articles about Benzenemethanol, a-butyl-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-butane (109-65-9) + 4-methoxy-benzaldehyde (123-11-5) → 1-(4-methoxyphenyl)pentanol (19523-03-6)

Guidance literature:

1-bromo-butane; With magnesium; ethylene dibromide; In 2-methyltetrahydrofuran; at 20 ℃; Inert atmosphere;

4-methoxy-benzaldehyde; In 2-methyltetrahydrofuran; at 0 - 20 ℃; for 1.25h; chemoselective reaction; Inert atmosphere;

DOI:10.3184/030823409X460939

Reference yield: 57.0%

n-pentylmagnesium bromide (693-25-4) + 4-methoxy-benzaldehyde (123-11-5) → 1-(4-methoxyphenyl)pentanol (19523-03-6)

Guidance literature:

In tetrahydrofuran; at -40 - 20 ℃; for 11h; Sealed tube; Inert atmosphere;

DOI:10.1021/acschemneuro.1c00762

Reference yield: 50.0%

tributyl borane (122-56-5) + p-methoxybenzal chloride (21185-25-1) → 1-(4-methoxyphenyl)pentanol (19523-03-6) + 2,2-dimethyl-1-(p-methoxyphenyl)propyl chloride (91561-63-6)

Guidance literature:

With sodium perborate; tert.-butyl lithium; In tetrahydrofuran; 1.) -78 deg C, 0.5 h; 2.) r.t., 2 h;

DOI:10.1016/0040-4039(95)01870-N

upstream raw materials:

n-butyl magnesium bromide

4-methoxy-benzaldehyde

n-butyllithium

trimethyltelluronium iodide

Downstream raw materials:

Bernsteinsaeure-<1-(4-methoxy-phenyl)-pentyl>-ester

Decansaeure-<1-(4-methoxy-phenyl)-pentyl>-ester

N-(1-(4-methoxyphenyl)pentyl)-4-methylbenzenesulfonamide

1-(4-methoxy-3-nitrophenyl)-pentan-1-one

Refernces

• 1、 -. "Aminophenone compounds as well as preparation method and application thereof". Paragraph 0047-0050; 0229-0233. . Retrieved 2021/02/06.
• 2、 Deibl, Nicklas,Ament, Kevin,Kempe, Rhett. "A sustainable multicomponent pyrimidine synthesis". supporting information. p. 12804 - 12807. Retrieved 2015/10/28.