2-Phenyl-tetrahydrofuran

Base Information

• Chemical Name: 2-Phenyl-tetrahydrofuran
• CAS No.: 16133-83-8
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID30936484
• Nikkaji Number: J864.624D
• Mol file: 16133-83-8.mol

Synonyms:2-phenyl-tetrahydrofuran;16133-83-8;2-phenyltetrahydrofuran;2-phenyloxolane;2-phenyl-tetrahydro-furan;phenyltetrahydrofuran;SCHEMBL28414;DTXSID30936484;FURAN, TETRAHYDRO-2-PHENYL-;MFCD00961901;AKOS006372448;PB14199;AS-34174;AM20030084;CS-0051806;FT-0685172;A883120;W-205877

Chemical Property of 2-Phenyl-tetrahydrofuran

Chemical Property:

• Melting Point: 91-92 °C
• Boiling Point: 105 °C(Press: 14 Torr)
• PSA: 9.23000
• Density: 1.037 g/cm3(Temp: 15 °C)
• LogP: 2.53810
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 148.088815002
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

97% ^*data from raw suppliers

2-Phenyloxolane 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(OC1)C2=CC=CC=C2

Technology Process of 2-Phenyl-tetrahydrofuran

There total 96 articles about 2-Phenyl-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + bromobenzene (108-86-1,52753-63-6) → tetrahydro-2-phenylfuran (16133-83-8)

Guidance literature:

With nickel(II) bromide dimethoxyethane; dipotassium hydrogenphosphate; benzaldehyde; 4,4'-di-tert-butyl-2,2'-bipyridine; for 72h; Inert atmosphere; UV-irradiation;

DOI:10.1002/anie.201810526

Reference yield: 82.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + phenylmagnesium bromide (100-58-3) → tetrahydro-2-phenylfuran (16133-83-8)

Guidance literature:

With C₃₁H₃₈ClN₃NiO₂^(1-)*Li⁽¹⁺⁾; In ethylene dibromide; at 25 ℃; for 1h; Catalytic behavior; Inert atmosphere;

DOI:10.1007/s10562-013-1170-8

Reference yield: 70.0%

4-phenyl-butan-1-ol (3360-41-6) → tetrahydro-2-phenylfuran (16133-83-8)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; In 1,2-dichloro-ethane; at 60 - 70 ℃; for 2h; Irradiation;

DOI:10.1016/0040-4039(96)00313-9

upstream raw materials:

4-phenylbuta-3-en-1-ol

trimethylene oxide

methanol

phenyldiazomethane

Downstream raw materials:

ethene

2,3-diphenyl-2,3-butanediol

1-Phenylethanol

acetophenone