2-Iodo-3-methoxyphenol

Base Information

• Chemical Name: 2-Iodo-3-methoxyphenol
• CAS No.: 121980-50-5
• Molecular Formula: C7H7IO2
• Molecular Weight: 250.036
• DSSTox Substance ID: DTXSID60555945
• Wikidata: Q82437402
• Mol file: 121980-50-5.mol

Synonyms:2-iodo-3-methoxyphenol;121980-50-5;Phenol, 2-iodo-3-methoxy-;2-iodo-3-methoxy-phenol;2-iodo-3-(methyloxy)phenol;SCHEMBL2045969;DTXSID60555945;DLVPKRMLAXQBGK-UHFFFAOYSA-N;MB14766;G14880;A1-02957

Chemical Property of 2-Iodo-3-methoxyphenol

Chemical Property:

• Boiling Point: 248 °C at 760 mmHg
• Flash Point: 103.8 °C
• PSA: 29.46000
• Density: 1.866 g/cm³
• LogP: 2.00540
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 249.94908
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98%min ^*data from raw suppliers

2-Iodo-3-methoxyphenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1I)O

Technology Process of 2-Iodo-3-methoxyphenol

There total 15 articles about 2-Iodo-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-iodo-1-(methyloxy)-3-{[(methyloxy)methyl]oxy}benzene (81245-39-8) → 2-iodo-3-(methyloxy)phenol (121980-50-5)

Guidance literature:

With hydrogenchloride; In methanol; water; for 0.333333h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.9b03557

Reference yield: 78.0%

2-iodo-3-methoxyphenoyl N,N-diethyl O-carbamate → 2-iodo-3-(methyloxy)phenol (121980-50-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 8h; Reflux;

DOI:10.1002/anie.201410751

Reference yield: 45.0%

methanol (67-56-1) + 2-iodoresorcinol (41046-67-7) → 2-iodo-3-(methyloxy)phenol (121980-50-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 12h;

upstream raw materials:

1-methoxy-3-(methoxymethoxy)benzene

2-iodo-1-(methyloxy)-3-{[(methyloxy)methyl]oxy}benzene

2-bromoanisole

Benzoic acid 2-iodo-3-methoxy-phenyl ester

Downstream raw materials:

1-But-3-enyloxy-2-iodo-3-methoxy-benzene

2-Iodo-1-methoxy-3-((E)-3-phenyl-allyloxy)-benzene

(E)-4-(2-Iodo-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

5-(2-Iodo-3-methoxy-phenoxy)-5H-furan-2-one