2,3-Dichloro-6-nitroaniline

Base Information

• Chemical Name: 2,3-Dichloro-6-nitroaniline
• CAS No.: 65078-77-5
• Molecular Formula: C6H4Cl2N2O2
• Molecular Weight: 207.016
• European Community (EC) Number: 265-378-3
• DSSTox Substance ID: DTXSID20983629
• Nikkaji Number: J286.650A
• Wikidata: Q82970551
• Mol file: 65078-77-5.mol

Synonyms:2,3-Dichloro-6-nitroaniline;65078-77-5;EINECS 265-378-3;Benzenamine, 2,3-dichloro-6-nitro-;MFCD00110529;SCHEMBL5635430;6-Nitroaniline, 2,3-dichloro-;AMY8661;DTXSID20983629;RDCOVUDTFKIURA-UHFFFAOYSA-N;AKOS015890724;SB78221;AS-10117;SY039015;CS-0060318;FT-0701120;EN300-185711;A856082;W-109245

Chemical Property of 2,3-Dichloro-6-nitroaniline

Chemical Property:

• Vapor Pressure: 0.000261mmHg at 25°C
• Refractive Index: 1.655
• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• PSA: 71.84000
• Density: 1.624 g/cm³
• LogP: 3.58820
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 205.9649828
• Heavy Atom Count: 12
• Complexity: 185

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloro-6-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1[N+](=O)[O-])N)Cl)Cl

Technology Process of 2,3-Dichloro-6-nitroaniline

There total 10 articles about 2,3-Dichloro-6-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

4-nitro-1,2,3-trichlorobenzene (17700-09-3) → 2,3-dichloro-6-nitroaniline (65078-77-5)

Guidance literature:

With ammonia; In chlorobenzene; at 145 ℃; for 5h; Temperature; Autoclave; Large scale;

Reference yield: 75.0%

3,4-dichloronitrobenzene (99-54-7) → 2,3-dichloro-6-nitroaniline (65078-77-5) + 4,5-dichloro-2-nitroaniline (6641-64-1)

Guidance literature:

With O-Methylhydroxylamin; potassium tert-butylate; copper diacetate; In monoethylene glycol diethyl ether; at 20 ℃; for 2h;

DOI:10.1039/a901537j

Reference yield: 55.0%

N-(2,3-dichlorophenyl)-acetamide (23068-36-2) → 2,3-dichloro-6-nitroaniline (65078-77-5) + 2,3-dichloro-4-nitroaniline (69951-03-7)

Guidance literature:

N-(2,3-dichlorophenyl)-acetamide; With sulfuric acid; potassium nitrate; at 2 - 5 ℃; for 4h;

With sulfuric acid; at 100 - 110 ℃; for 2h;

DOI:10.1016/j.bmc.2007.01.005

upstream raw materials:

4-nitro-1,2,3-trichlorobenzene

2,3-dichloro-6-nitroacetanilide

2,3-dichloroformanilide

3,4-dichloronitrobenzene

Downstream raw materials:

3,4-dichloronitrobenzene

1,2-dichloro-3,4-dinitrobenzene

2,3-dichloro-6-nitroacetanilide

3,4-dichloro-1,2-phenylenediamine