N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide

Base Information

Chemical Name:N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide
CAS No.:261763-57-9
Molecular Formula:C₄₉H₄₆Cl₂N₄O₆
Molecular Weight:857.833
Hs Code.:

<i>N</i>-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[<i>e</i>]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1<i>H</i>-benzo[<i>e</i>]indol-7-yl}-acetamide

Synonyms:

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Chemical Property of N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide

There total 5 articles about N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2873-74-7
gloutaric dichloride

: N-(5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl)-acetamide; hydrochloride

: 261763-57-9
N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 4h;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 286374-31-0
7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

: 261763-57-9
N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

2: 4N HCl / dioxane / 5 h / 0 - 23 °C

3: 0.1172 g / Et₃N / dimethylformamide / 4 h / 23 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Acetylation / 2: Hydrolysis / 3: Acylation;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 222835-56-5
5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

: 261763-57-9
N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / TBAF / tetrahydrofuran / 1 h / 23 °C

2: 92 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

3: 4N HCl / dioxane / 5 h / 0 - 23 °C

4: 0.1172 g / Et₃N / dimethylformamide / 4 h / 23 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Substitution / 2: Acetylation / 3: Hydrolysis / 4: Acylation;
DOI:10.1016/S0968-0896(00)00088-2