6-Fluoro-1-methylbenzoimidazole

Base Information

• Chemical Name: 6-Fluoro-1-methylbenzoimidazole
• CAS No.: 1187385-86-9
• Molecular Formula: C₈H₇FN₂
• Molecular Weight: 150.155
• Hs Code.: 2933990090
• Mol file: 1187385-86-9.mol

Synonyms:6-Fluoro-1-methylbenzoimidazole;6-Fluoro-1-methyl-1H-benzo[d]imidazole

Chemical Property of 6-Fluoro-1-methylbenzoimidazole

Chemical Property:

• Boiling Point: 260.3±32.0 °C(Predicted)
• PKA: 4.63±0.10(Predicted)
• PSA: 17.82000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 1.71240
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

6-Fluoro-1-methylbenzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-1-methylbenzoimidazole

There total 2 articles about 6-Fluoro-1-methylbenzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formic acid (64-18-6) + 4-fluoro-2-methylaminonitrobenzene (120381-42-2) → 6-fluoro-1-methyl-1H-benzo[d]imidazole (1187385-86-9)

Guidance literature:

With iron; ammonium chloride; In isopropyl alcohol; at 85 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1515/znb-2016-0195

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) → 6-fluoro-1-methyl-1H-benzo[d]imidazole (1187385-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 1.75 h / 0 °C / Inert atmosphere; Sealed tube

2: iron; ammonium chloride / isopropyl alcohol / 4 h / 85 °C / Inert atmosphere; Sealed tube

With iron; ammonium chloride; In water; isopropyl alcohol;

DOI:10.1515/znb-2016-0195

upstream raw materials:

formic acid

4-fluoro-2-methylaminonitrobenzene

2,4-Difluoronitrobenzene

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