Thiazole-2,4-diamine hydrochloride

Base Information

• Chemical Name: Thiazole-2,4-diamine hydrochloride
• CAS No.: 67355-26-4
• Molecular Formula: C3H5N3S
• Molecular Weight: 115.159
• European Community (EC) Number: 825-300-6
• NSC Number: 139725,13543
• DSSTox Substance ID: DTXSID20986615
• Mol file: 67355-26-4.mol

Synonyms:Thiazole-2,4-diamine hydrochloride;72792-54-2;1,3-Thiazole-2,4-diamine hydrochloride;1,3-thiazole-2,4-diamine;hydrochloride;MFCD01438626;SCHEMBL20475963;DTXSID20986615;Thiazole-2,4-diaminehydrochloride;NSC13543;NSC-13543;NSC139725;AKOS016025423;2,4-Diaminothiazole, monohydrochloride;CS-W006972;NSC-139725;AC-27240;DS-17124;D70972;1,3-Thiazole-2,4-diamine hydrochloride (1:1);A866200;Z190661742;2-Imino-2,3-dihydro-1,3-thiazol-4-amine--hydrogen chloride (1/1)

Chemical Property of Thiazole-2,4-diamine hydrochloride

Chemical Property:

• PSA: 93.17000
• LogP: 2.27190
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 150.9970961
• Heavy Atom Count: 8
• Complexity: 67.2

Purity/Quality:

97% ^*data from raw suppliers

Thiazole-2,4-diamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(S1)N)N.Cl
• Uses: Thiazole-2,4-diamine is used as a reactant in the preparation of thiazoles as well as reactive modifications of thiazole moieties.

Technology Process of Thiazole-2,4-diamine hydrochloride

There total 1 articles about Thiazole-2,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-{2-[3-(2-{[(4'-hydroxybiphenyl-3-yl)methyl]amino}-2-oxoethyl)phenyl]-1,1-dimethylethyl}acetamide + chloroacetonitrile (107-14-2) + thiourea (17356-08-0) → 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide (921598-21-2) + 2,4-diamino thiazole (67355-26-4) + pseudothiohydantoin (556-90-1)

Guidance literature:

With acetic acid; In water; iso-butanol; at 20 ℃; for 5h; Reflux; Large scale;

DOI:10.1021/op300341n

Reference yield:

2,4-diamino thiazole (67355-26-4) + α-bromoacetophenone (70-11-1) → 2-(2,4-diimino-thiazolidin-3-yl)-1-phenyl-ethanone (804443-57-0)

Guidance literature:

In ethanol;

upstream raw materials:

chloroacetonitrile

thiourea

Downstream raw materials:

2-(2,4-diimino-thiazolidin-3-yl)-1-phenyl-ethanone