Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

Base Information

Chemical Name:Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester
CAS No.:128901-58-6
Molecular Formula:C₃₇H₆₂N₅O₁₀P
Molecular Weight:767.901
Hs Code.:

Iva-Val-Val-Leu<sup>P</sup>-(O)Phe-Ala-Ala dimethyl ester

Synonyms:

Suppliers and Price of Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

There total 8 articles about Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90763-55-6
C₁₄H₂₁ClNO₄P

: 128901-58-6,128948-81-2
Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 48 h

2: H₂ / 10percent Pd/C / ethyl acetate / 3.5 h

3: 1) N-methylmorpholine, isobutyl chloroformate / 1) EtOAc, -10 deg C, 3 min, 2a) -10 deg C, 1 h, 2b) r.t., overnight

With 4-methyl-morpholine; hydrogen; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012

Reference yield:

: 128948-77-6
<(1R)-1-amino>-3-methylbutyl>phosphonic acid

: 128901-58-6,128948-81-2
Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / 9 h / 110 °C

2: 95 percent / 2 N NaOH / methanol / 12 h / 21 °C

3: SOCl₂ / CH₂Cl₂ / 4 h

4: Et₃N / CH₂Cl₂ / 48 h

5: H₂ / 10percent Pd/C / ethyl acetate / 3.5 h

6: 1) N-methylmorpholine, isobutyl chloroformate / 1) EtOAc, -10 deg C, 3 min, 2a) -10 deg C, 1 h, 2b) r.t., overnight

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; hydrogen; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012

Reference yield:

: 128948-78-7
methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

: 128901-58-6,128948-81-2
Iva-Val-Val-Leu^P-(O)Phe-Ala-Ala dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / CH₂Cl₂ / 4 h

2: Et₃N / CH₂Cl₂ / 48 h

3: H₂ / 10percent Pd/C / ethyl acetate / 3.5 h

4: 1) N-methylmorpholine, isobutyl chloroformate / 1) EtOAc, -10 deg C, 3 min, 2a) -10 deg C, 1 h, 2b) r.t., overnight

With 4-methyl-morpholine; thionyl chloride; hydrogen; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012