2-Dimethoxyphosphorylpropan-2-ol

Base Information

• Chemical Name: 2-Dimethoxyphosphorylpropan-2-ol
• CAS No.: 10184-68-6
• Molecular Formula: C5H13O4P
• Molecular Weight: 168.13
• DSSTox Substance ID: DTXSID60381680
• Wikidata: Q82172660
• Mol file: 10184-68-6.mol

Synonyms:2-dimethoxyphosphorylpropan-2-ol;10184-68-6;dimethyl (1-hydroxy-1-methylethyl)phosphonate;Phosphonic acid, (1-hydroxy-1-methylethyl)-, dimethyl ester (6CI,7CI,8CI,9CI);ST50996204;SCHEMBL7445196;DTXSID60381680;XKBAMTNWFFDMLF-UHFFFAOYSA-N;AKOS024364209;dimethyl (2-hydroxypropan-2-yl)phosphonate;dimethyl 1-hydroxy-1-methylethylphosphonate;FT-0767706

Chemical Property of 2-Dimethoxyphosphorylpropan-2-ol

Chemical Property:

• PSA: 65.57000
• LogP: 1.20070
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 168.05514589
• Heavy Atom Count: 10
• Complexity: 146

Purity/Quality:

98%,99%, ^*data from raw suppliers

DIMETHYL (1-HYDROXY-1-METHYLETHYL)PHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(O)P(=O)(OC)OC

Technology Process of 2-Dimethoxyphosphorylpropan-2-ol

There total 8 articles about 2-Dimethoxyphosphorylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Dimethyl phosphite (868-85-9) + acetone (67-64-1) → dimethyl (1-hydroxy-1-methylethyl)phosphonate (10184-68-6)

Guidance literature:

Dimethyl phosphite; acetone; With calcium fluoride; for 0.0833333h;

With potassium hydroxide; at 40 - 50 ℃; for 5.16667h;

Reference yield:

Dimethyl phosphite (868-85-9) + acetone (67-64-1) + methyl iodide (74-88-4) → dimethyl (1-hydroxy-1-methylethyl)phosphonate (10184-68-6) + dimethyl methane phosphonate (756-79-6)

Guidance literature:

With NaCN*14-crown-5; In dichloromethane; at -30 ℃; Yield given. Yields of byproduct given;

Reference yield:

methyl phosphite (96-36-6,868-85-9) + acetone (67-64-1) → dimethyl (1-hydroxy-1-methylethyl)phosphonate (10184-68-6)

Guidance literature:

With sodium methylate;

upstream raw materials:

methyl phosphite

acetone

Dimethyl phosphite

methyl iodide

Downstream raw materials:

dimethyl <1-(bromomethyl)ethenyl>phosphonate