Technology Process of 2-Acetyl-5-(3,5-dibrom-2-methoxyphenyl)-1-phenylsulfonylpyrrol
There total 11 articles about 2-Acetyl-5-(3,5-dibrom-2-methoxyphenyl)-1-phenylsulfonylpyrrol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / 1 h / Heating
2: 1.) Mg
3: 56 percent / CH3CO2NH4 / acetic acid / Heating
4: 1.) NaH / 1.) DMF, room temperature; 2.) DMF, room temperature, 1 h
5: 1.) Et2O-BF3 / 1.) 1,2-dichloroethane, 25 deg C, 10 min; 2.) 1,2-dichloroethane, 25 deg C, 1.5 h
With
thionyl chloride; boron trifluoride diethyl etherate; ammonium acetate; sodium hydride; magnesium;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / KOH / methanol; H2O / 4 h / Heating
2: thionyl chloride / 1 h / Heating
3: 1.) Mg
4: 56 percent / CH3CO2NH4 / acetic acid / Heating
5: 1.) NaH / 1.) DMF, room temperature; 2.) DMF, room temperature, 1 h
6: 1.) Et2O-BF3 / 1.) 1,2-dichloroethane, 25 deg C, 10 min; 2.) 1,2-dichloroethane, 25 deg C, 1.5 h
With
potassium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; ammonium acetate; sodium hydride; magnesium;
In
methanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Mg
2: 56 percent / CH3CO2NH4 / acetic acid / Heating
3: 1.) NaH / 1.) DMF, room temperature; 2.) DMF, room temperature, 1 h
4: 1.) Et2O-BF3 / 1.) 1,2-dichloroethane, 25 deg C, 10 min; 2.) 1,2-dichloroethane, 25 deg C, 1.5 h
With
boron trifluoride diethyl etherate; ammonium acetate; sodium hydride; magnesium;
In
acetic acid;
