13130-23-9

Usage

Uses

Used in Organic Synthesis:
3,5-DIBROMO-2-METHOXYBENZOIC ACID is used as a building block in organic synthesis for the creation of more complex organic molecules. Its unique structure allows for the formation of various derivatives, making it a valuable component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3,5-DIBROMO-2-METHOXYBENZOIC ACID is utilized as a key intermediate in the development of new drugs. Its chemical properties and reactivity make it a promising candidate for the synthesis of pharmaceutical agents with potential therapeutic applications.
Used as a Reagent in Chemical Reactions:
3,5-DIBROMO-2-METHOXYBENZOIC ACID also serves as a reagent in various chemical reactions, facilitating the synthesis of different organic compounds. Its presence in these reactions can enhance the yield and selectivity of the desired products, contributing to the advancement of chemical research and development.
Used as a Starting Material for Synthesis:
Furthermore, 3,5-DIBROMO-2-METHOXYBENZOIC ACID is employed as a starting material for the synthesis of a variety of organic compounds. Its versatile structure allows for the generation of new molecules with potential applications in various industries, such as agriculture, materials science, and environmental science.

InChI:InChI=1/C8H6Br2O3/c1-13-7-5(8(11)12)2-4(9)3-6(7)10/h2-3H,1H3,(H,11,12)

Upstream product

• 607-99-8 2,4,6-tribromoanisole 
• 3147-55-5 3,5-dibromosalicylic acid 
• 77-78-1 dimethyl sulfate 
• 15790-59-7 3,5-dibromo-2-methoxy-benzoic acid methyl ester 
• 61657-65-6 3,5-dibromo-2-methoxybenzaldehyde 
• 90-59-5 3,5-Dibromosalicylaldehyde 
• 74-88-4 methyl iodide 
• 90-02-8 salicylaldehyde 
• 69-72-7 salicylic acid 
• 67-64-1 acetone 
• 7697-37-2 nitric acid 
• 24591-33-1 4-bromo-2-isopropylanisole 
• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 

Downstream Products

• 15790-59-7 3,5-dibromo-2-methoxy-benzoic acid methyl ester 
• 90798-58-6 3,5-dibromo-2-methoxy-benzoic acid ethyl ester 
• 98527-09-4 (S)-(-)-3,5-dibromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide 
• 98527-10-7 (S)-(-)-3,5-dibromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]salicylamide 
• 2577-72-2 3,5-dibromo-2-hydroxy-N-phenylbenzamide 
• 130880-37-4 3,5-dibromo-2-methoxy-N-(1-benzyl-4-piperidinyl)benzamide 
• 121789-72-8 2,7,12-Tris-(3,5-dibrom-2-methoxyphenyl)-4,4a,9,9a,14,14a-hexahydro-3H,8H,13H-tripyradizino<1,6-a:1',6'-c:1',6'-e>-s-triazin 
• 121789-67-1 1,4-Bis(3,5-dibrom-2-methoxyphenyl)-2-methylisoindol 
• 121789-74-0 2-Acetyl-5-(3,5-dibrom-2-methoxyphenyl)-1-phenylsulfonylpyrrol 
• 121789-73-9 2-(3,5-Dibrom-2-methoxyphenyl)-1-phenylsulfonylpyrrol 
• 121789-71-7 2,3,4-Tribrom-5-(3,5-dibrom-2-methoxyphenyl)-1-methylpyrrol 
• 121789-28-4 1-(3,5-Dibrom-2-methoxyphenyl)-3-(1,3-dioxan-2-yl)-1-propanon 
• 121789-27-3 1-(3,5-Dibrom-2-hydroxyphenyl)-3-(1,3-dioxan-2-yl)-1-propanon 
• 121789-25-1 1-(3,5-Dibrom-2-methoxyphenyl)-3-(1,3-dioxolan-2-yl)-1-propanon 

Relevant academic research and scientific papers

3,5-Dibromo-2-methoxybenzoic acid from sea sponge Didiscus sp.

3,5-Dibromo-2-methoxybenzoic acid was isolated from sea sponge Didiscus sp. The structure of the title compound was established by spectral methods, by X-ray diffraction analysis, and by comparing with a synthetic sample prepared from salicylaldehyde.

COMPOUNDS AND METHODS OF INHIBITING BACTERIAL CHAPERONIN SYSTEMS

The present disclosure relates to novel compounds and methods of killing or inhibiting the growth of bacteria. In some embodiments, a method of killing or inhibiting the growth of bacteria is provided. The method comprises administering a compound of formula I or a pharmaceutically acceptable salt thereof to bacteria. In some embodiments, a method of killing or inhibiting the growth of bacteria is provided. The method comprises administering an anthelmintic to bacteria.

Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus

We recently reported the identification of a GroEL/ES inhibitor (1, N-(4-(benzo[d]thiazol-2-ylthio)-3-chlorophenyl)-3,5-dibromo-2-hydroxybenzamide) that exhibited in vitro antibacterial effects against Staphylococcus aureus comparable to vancomycin, an antibiotic of last resort. To follow up, we have synthesized 43 compound 1 analogs to determine the most effective functional groups of the scaffold for inhibiting GroEL/ES and killing bacteria. Our results identified that the benzothiazole and hydroxyl groups are important for inhibiting GroEL/ES-mediated folding functions, with the hydroxyl essential for antibacterial effects. Several analogs exhibited >50-fold selectivity indices between antibacterial efficacy and cytotoxicity to human liver and kidney cells in cell culture. We found that MRSA was not able to easily generate acute resistance to lead inhibitors in a gain-of-resistance assay and that lead inhibitors were able to permeate through established S. aureus biofilms and maintain their bactericidal effects.

A cyclotrimethoxone-substituted salicylate compound and anti-tumor effect thereof

The invention relates to the technical field of medicines, and designs and synthesizes a novel A cyclotrimethoxy 4'-hydroxyflavone compound and an A cyclotrimethoxone-substituted salicylate compound. The figure 1 is a general formula of the A cyclotrimethoxone-substituted salicylate compound, wherein in the formula, R1, R2 and R3 are equal to OCH3 or R2, R3 and R4 are equal to OCH3; R5- is equal to OCH3, CH3, F, Cl, Br, I or the like. The novel A cyclotrimethoxy 4'-hydroxyflavone compound and the A cyclotrimethoxone-substituted salicylate compound can have an obvious inhibiting effect on MGC-803 (human gastric carcinoma cells), HepG2 (human hepatoma carcinoma cells), MCF-7 (human breast cancer cells) and hopefully become anti-tumor drugs. The invention discloses a preparation method of the novel A cyclotrimethoxy 4'-hydroxyflavone compound and the A cyclotrimethoxone-substituted salicylate compound.

Acyl derivatives of 2-aminobenzimidazole and their fungicide activity

Procedures have been developed for the preparation of methyl 2-benzimidazolylcarbamate, 2-acetylaminobenzimidazole, 2- benzoylaminobenzimidazole, 2-(3,5-dibromo-2-hydroxybenzoylamino)benzimidazole, 1-(3,6-dichloro-2-methoxybenzoyl)-2-aminobenzimidazole, 2-(3,5-dichloro-2- hydroxybenzoylamino)benzimidazole, 2-(3,5-dichloro-2-methoxybenzoylamino) benzimidazole, and 1-(3,5,6-trichloro-2-methoxybenzoyl)-2-aminobenzimidazole. The synthesized compounds have been tested for fungicide activity.

Marine Bacteria, I. - Synthesis of Pentabromopseudiline, a Cytotoxic Phenylpyrrole from Alteromonas luteo-violaceus

A new synthesis of 2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)pyrrole (1a, pentabromopseudiline), an antibiotic, enzymeinhibitory and cytotoxic active constituent of the marine bacterium Alteromonas luteo-violaceus, is described.For investigation of structure-activity relationships further 2-phenylpyrroles are investigated.Key step in their synthesis is the Grignard reaction of 2-(1,3-dioxan-2-yl)ethylmagnesium bromide (9d) with benzoyl chlorides yielding γ-phenyl-γ-ketoaldehydes 24, and the Paal-Knorr cyclisation of the latter. - Key Words: Alteromonas luteo-violaceus / Bromopyrrole / Marine bacteria / Pentabromopseudiline