(2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

Base Information

Chemical Name:(2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide
CAS No.:1369534-86-0
Molecular Formula:C₂₁H₁₅F₃N₂O
Molecular Weight:368.358
Hs Code.:

Synonyms:

Suppliers and Price of (2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

There total 6 articles about (2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1125-60-6
isoquinolin-5-ylamine

: 203722-39-8
(E,E)-5-(4-trifluoromethylphenyl)-2,4-pentadienoic acid

: 1369534-86-0
(2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 60 ℃; for 7h; Inert atmosphere;
DOI:10.1021/jm300101n

Reference yield:

: 20754-22-7
methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate

: 1369534-86-0
(2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 5 h / -78 °C / Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 24 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C / Inert atmosphere

4.2: 1 h / pH 5 / Inert atmosphere

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

With manganese(IV) oxide; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300101n

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1369534-86-0
(2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 5 h / -78 °C / Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C / Inert atmosphere

5.2: 1 h / pH 5 / Inert atmosphere

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

With manganese(IV) oxide; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Horner-Wadsworth-Emmons olefination / 4.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300101n