2,4-Pentadienoic acid, 5-[4-(trifluoroMethyl)phenyl]-, (2E,4E)-

Base Information

• Chemical Name: 2,4-Pentadienoic acid, 5-[4-(trifluoroMethyl)phenyl]-, (2E,4E)-
• CAS No.: 203722-39-8
• Molecular Formula: C12H9F3O2
• Molecular Weight: 242.197
• Mol file: 203722-39-8.mol

Synonyms:2,4-Pentadienoic acid, 5-[4-(trifluoroMethyl)phenyl]-, (2E,4E)-

Chemical Property of 2,4-Pentadienoic acid, 5-[4-(trifluoroMethyl)phenyl]-, (2E,4E)-

Chemical Property:

• PSA: 37.30000
• LogP: 3.35940

Purity/Quality:

97% ^*data from raw suppliers

(2E,4E)-5-(4-(Trifluoromethyl)phenyl)penta-2,4-dienoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Pentadienoic acid, 5-[4-(trifluoroMethyl)phenyl]-, (2E,4E)-

There total 5 articles about 2,4-Pentadienoic acid, 5-[4-(trifluoroMethyl)phenyl]-, (2E,4E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (2E,4E)-5-((p-(trifluoromethyl))phenyl)penta-2,4-dienoate (443360-58-5) → (E,E)-5-(4-trifluoromethylphenyl)-2,4-pentadienoic acid (203722-39-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 5 ℃; Inert atmosphere;

Reference yield:

methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate (20754-22-7) → (E,E)-5-(4-trifluoromethylphenyl)-2,4-pentadienoic acid (203722-39-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 5 h / -78 °C / Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 24 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C / Inert atmosphere

4.2: 1 h / pH 5 / Inert atmosphere

With manganese(IV) oxide; diisobutylaluminium hydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 3.1: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jm300101n

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → (E,E)-5-(4-trifluoromethylphenyl)-2,4-pentadienoic acid (203722-39-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 5 h / -78 °C / Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C / Inert atmosphere

5.2: 1 h / pH 5 / Inert atmosphere

With manganese(IV) oxide; diisobutylaluminium hydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1.1: Horner-Wadsworth-Emmons olefination / 4.1: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jm300101n

upstream raw materials:

methyl (2E,4E)-5-((p-(trifluoromethyl))phenyl)penta-2,4-dienoate

4-Trifluoromethylbenzaldehyde

methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate

(2E)-3-(4-trifluoromethylphenyl)prop-2-enal

Downstream raw materials:

(2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide