2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester
CAS No.:117325-99-2
Molecular Formula:C₅₆H₈₀O₁₂Si₂
Molecular Weight:1001.41
Hs Code.:

2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

There total 9 articles about 2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3282-30-2
pivaloyl chloride

: 117325-99-2
2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / pyridine / DMAP / CH₂Cl₂ / Ambient temperature

2: 1.) HgCl₂, CdCO₃, 2.) NaBH₃CN, further reducing agent and solvent / 1.) acetone-water, 2.) dimethoxyethane

3: 97 percent / silver perchlorate, 4-Angstroem molecular sieves / acetonitrile / -40 °C

4: 2.) pyridine

5: Bu₄NI, DMAP, diisopropylethylamine / tetrahydrofuran / 96 h / Ambient temperature

With pyridine; dmap; cadmium(II) carbonate; 4 A molecular sieve; silver perchlorate; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; mercury dichloride; dmap; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)80342-1

Reference yield:

: 225797-51-3
(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

: 117325-99-2
2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / dimethylformamide

2: p-toluenesulfonic acid / methanol

3: 98 percent / pyridine / DMAP / CH₂Cl₂ / Ambient temperature

4: 1.) HgCl₂, CdCO₃, 2.) NaBH₃CN, further reducing agent and solvent / 1.) acetone-water, 2.) dimethoxyethane

5: 97 percent / silver perchlorate, 4-Angstroem molecular sieves / acetonitrile / -40 °C

6: 2.) pyridine

7: Bu₄NI, DMAP, diisopropylethylamine / tetrahydrofuran / 96 h / Ambient temperature

With pyridine; dmap; cadmium(II) carbonate; 4 A molecular sieve; silver perchlorate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; mercury dichloride; dmap; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)80342-1

Reference yield:

: 117325-94-7
5-O-[(4-Methoxyphenyl)diphenylmethyl]-2,3,4-tris-O-(phenylmethyl)-D-ribose-diethyldithioacetal

: 117325-99-2
2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,3aR,9aR)-3-benzyloxymethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yloxy)-pentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonic acid / methanol

2: 98 percent / pyridine / DMAP / CH₂Cl₂ / Ambient temperature

3: 1.) HgCl₂, CdCO₃, 2.) NaBH₃CN, further reducing agent and solvent / 1.) acetone-water, 2.) dimethoxyethane

4: 97 percent / silver perchlorate, 4-Angstroem molecular sieves / acetonitrile / -40 °C

5: 2.) pyridine

6: Bu₄NI, DMAP, diisopropylethylamine / tetrahydrofuran / 96 h / Ambient temperature

With pyridine; dmap; cadmium(II) carbonate; 4 A molecular sieve; silver perchlorate; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; mercury dichloride; dmap; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)80342-1