3034-65-9

Usage

Classification

Diazepinone derivative, Benzodiazepine class
1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE belongs to the diazepinone derivatives and is part of the larger benzodiazepine class of compounds, which are known for their psychoactive properties.

Psychoactive effects

Sedative, anxiolytic, muscle relaxant, and anticonvulsant
1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE may have various psychoactive effects, including sedation, reduction of anxiety, muscle relaxation, and prevention of seizures.

Medical uses

Treatment of anxiety disorders, insomnia, and seizures
1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE is often used in the treatment of various medical conditions, such as anxiety disorders, difficulty sleeping (insomnia), and seizure disorders.

Dosage and individual response

Effects may vary
The specific effects of 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE may differ depending on the dosage taken and the individual's response to the compound.

Professional guidance

Use under the guidance of a healthcare professional
To avoid potential side effects and adverse reactions, it is important to use 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE under the supervision and guidance of a qualified healthcare professional.

Upstream product

• 74-87-3 methylene chloride 
• 2898-08-0 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one 
• 14439-71-5 2'-benzoyl-2-bromo-acetanilide 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 1219505-77-7 C₃₄H₄₂N₄O₅ 
• 1219505-78-8 C₃₄H₄₂N₄O₅ 
• 74-88-4 methyl iodide 

Downstream Products

• 103343-71-1 (Z)-1,3-dihydro-1-methyl-5-phenyl-3-(3-thienylmethylene)-2H-1,4-benzodiazepin-2-one 
• 103343-71-1 (E)-1,3-dihydro-1-methyl-5-phenyl-3-(3-thienylmethylene)-2H-1,4-benzodiazepin-2-one 
• 103373-62-2 1,3-dihydro-1-methyl-3-oximido-5-phenyl-2H-1,4-benzodiazepin-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM.

Method for inhibiting the proliferation of tumor cells

A method of inhibiting the proliferation of tumor cells is disclosed which comprises the treatment of such tumor cells with a benzodiazepine having a selective affinity to bind peripheral binding sites on the tumor cell in order to induce non-proliferation of said tumor cells.

Synthesis and Resolution of 3-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones

Two efficient synthetic routes to the 3-amino-1,4-benzodiazepin-2-ones 2 and 3 were developed.The first sequence was carried out in 55-60percent overall yield and involves a novel mercuric ion assisted ammonia displacement of the (alkylthio)glycinamide 14 to produce the key intermediate α-aminoglycinamide 15.The second approach features a practical two-step amination of the parent 1,4-benzodiazepine ring system 24 to afford the title compound 3 in 49percent overall yield from 2-aminobenzophenone.The 3-amino-1,4-benzodiazepine 3 was resolved via the separation of the corresponding diastereomeric phenylalanyl amides.The desired (-)-3 enantiomer was then liberated by use of the Edman degradation.

Benzophenone glycinamide derivatives

This invention is directed toward pharmacologically active compounds of the formula STR1 wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula STR2 in which Ra represents a hydrogen atom or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C--Rb wherein Rb represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R1 represents a hydrogen atom or a lower alkyl group; R2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R3 represents a phenyl, halophenyl or 2-pyridyl group And acid addition salts thereof. Also provided are methods for their preparation and intermediates thereof. These compounds exhibit activity as anticonvulsants, muscle relaxants and sedatives.