1,5-dihydrobenzindol-4(3H)-one

Base Information

• Chemical Name: 1,5-dihydrobenzindol-4(3H)-one
• CAS No.: 2731-96-6
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.199
• Mol file: 2731-96-6.mol

Synonyms:

Chemical Property of 1,5-dihydrobenzindol-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,5-dihydrobenzindol-4(3H)-one

There total 1 articles about 1,5-dihydrobenzindol-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(prop-2-yn-1-yl)-1H-indole (7394-63-0) → 1,5-dihydrobenzindol-4(3H)-one (2731-96-6) + 1,2,3,4-tetrahydro-cyclopentindol-2-one (150670-63-6)

Guidance literature:

With 2-(tert-butyl)-6-chloropyridine 1-oxide; C₄₅H₅₇AuF₆NO₉PS₂; In chloroform; at 60 ℃; for 0.5h; Overall yield = 65 %;

DOI:10.1002/anie.201301015

Reference yield: 49.0%

1,5-dihydrobenzindol-4(3H)-one (2731-96-6) + dimethyl amine (124-40-3) → 4-(dimethylamino)-1,3,4,5-tetrahydrobenzindole (73625-11-3)

Guidance literature:

With N,N-dimethylammonium chloride; sodium cyanoborohydride; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jo00199a004

Reference yield:

1,5-dihydrobenzindol-4(3H)-one (2731-96-6) → 1-tosyl-4-tosyloxy-1,3,4,5-tetrahydrobenz[cd]indole

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / NaBH₄

2: 1.) NaH

With sodium tetrahydroborate; sodium hydride;

DOI:10.3987/COM-94-6738

upstream raw materials:

3-(prop-2-yn-1-yl)-1H-indole

Downstream raw materials:

4-(dimethylamino)-1,3,4,5-tetrahydrobenzindole