(Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

Base Information

Chemical Name:(Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide
CAS No.:1883595-39-8
Molecular Formula:C₁₇H₁₄FN₃O₃S
Molecular Weight:359.381
Hs Code.:

Synonyms:

Suppliers and Price of (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 8 raw suppliers

Chemical Property of (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

Chemical Property:

Boiling Point:613.9±65.0 °C(Predicted)
PKA:-0.33±0.53(Predicted)
Density:1.34±0.1 g/cm3(Predicted)

Purity/Quality:: 99.0% Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (Z)-N-((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine Oxide is an impurity of Vonoprazan a novel potassium-?competitive acid blocker for the treatment of acid-?related diseases.

Technology Process of (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

There total 9 articles about (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 881677-11-8
5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 1883595-39-8
C₁₇H₁₄FN₃O₃S

Guidance literature:: With sodium hydrogencarbonate; magnesium sulfate; In dichloromethane; for 18h; Reflux;
DOI:10.1016/j.tet.2022.132669

Reference yield:

: 881674-06-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 1883595-39-8
C₁₇H₁₄FN₃O₃S

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2 h / 0 °C

1.2: 2 h / 25 °C

2.1: acetonitrile / 1 h / 80 °C

3.1: sodium hydride / tetrahydrofuran / 8 h / 0 °C

4.1: sodium hydrogencarbonate; magnesium sulfate / dichloromethane / 18 h / Reflux

With sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; magnesium sulfate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2022.132669

Reference yield:

: 312307-38-3
2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile

: 1883595-39-8
C₁₇H₁₄FN₃O₃S

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 2 h / 75 °C

2.1: triethylamine; palladium 10% on activated carbon; hydrogen / ethanol / 22 h / 25 °C

3.1: sodium hydride; tetraethylammonium bromide / water; tetrahydrofuran / 1 h / 0 °C

3.2: 3 h

4.1: water; hydrogen; nickel / tetrahydrofuran / 22 h / 25 °C

5.1: sodium hydrogencarbonate; magnesium sulfate / dichloromethane / 18 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; tetraethylammonium bromide; water; hydrogen; nickel; sodium hydride; sodium hydrogencarbonate; magnesium sulfate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tet.2022.132669