(2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal

Base Information

• Chemical Name: (2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal
• CAS No.: 1108739-00-9
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 1108739-00-9.mol

Synonyms:

Chemical Property of (2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal

There total 2 articles about (2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + N-benzoyl-2-piperidinecarboxaldehyde (133787-01-6) → (2R)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal + (2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal (1108739-00-9)

Guidance literature:

With iodine; copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.200804188

Reference yield:

methanol (67-56-1) + N-benzoyl-2-piperidinecarboxaldehyde (133787-01-6) → methyl (S)-1-benzoylpiperidine-2-carboxylate (474011-77-3) + N-benzoyl-(2R)-(methoxycarbonyl)piperidine (1046767-90-1) + (2R)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal + (2S)-N-benzoylpiperidine-2-carboxaldehyde dimethylacetal (1108739-00-9)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.200804188

upstream raw materials:

methanol

N-benzoyl-2-piperidinecarboxaldehyde