Ethyl 3-(4-fluoroanilino)-3-oxopropanoate

Base Information

Chemical Name:Ethyl 3-(4-fluoroanilino)-3-oxopropanoate
CAS No.:104330-60-1
Molecular Formula:C11H12FNO3
Molecular Weight:225.22
Hs Code.:
DSSTox Substance ID:DTXSID60589285
Nikkaji Number:J2.235.432I
Wikidata:Q82482552
Mol file:104330-60-1.mol

Synonyms:104330-60-1;Ethyl 3-(4-fluoroanilino)-3-oxopropanoate;Propanoic acid, 3-[(4-fluorophenyl)amino]-3-oxo-, ethyl ester;ETHYL 2-[(4-FLUOROPHENYL)CARBAMOYL]ACETATE;ethyl 3-[(4-fluorophenyl)amino]-3-oxopropanoate;Ethyl 3-((4-fluorophenyl)amino)-3-oxopropanoate;Cabozantinib Impurity 5;SCHEMBL680836;DTXSID60589285;DVIGICXZLWQQCP-UHFFFAOYSA-N;AKOS003496867;DB-114427;ethyl 3-(4-fluorophenylamino)-3-oxopropanoate

Suppliers and Price of Ethyl 3-(4-fluoroanilino)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 3-(4-fluoroanilino)-3-oxopropanoate

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:225.08012141
Heavy Atom Count:16
Complexity:250

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CC(=O)NC1=CC=C(C=C1)F

Technology Process of Ethyl 3-(4-fluoroanilino)-3-oxopropanoate

There total 5 articles about Ethyl 3-(4-fluoroanilino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 36239-09-5
ethyl chlorocarbonylacetate

: 371-40-4
4-fluoroaniline

: 104330-60-1
3-((4-fluorophenyl)amino)-3-oxo-propionic acid ethyl ester

Guidance literature:: With triethylamine; In acetone; at 0 - 20 ℃;

Reference yield: 93.96%

: 371-40-4
4-fluoroaniline

: 105-53-3
diethyl malonate

: 104330-60-1
3-((4-fluorophenyl)amino)-3-oxo-propionic acid ethyl ester

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 1.5h; Solvent; Concentration;

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 371-40-4
4-fluoroaniline

: 104330-60-1
3-((4-fluorophenyl)amino)-3-oxo-propionic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 16h;