dimethyl rac-2,5-dibromohexanedioate

Base Information

• Chemical Name: dimethyl rac-2,5-dibromohexanedioate
• CAS No.: 124819-17-6
• Molecular Formula: C₈H₁₂Br₂O₄
• Molecular Weight: 331.989
• Mol file: 124819-17-6.mol

Synonyms:

Chemical Property of dimethyl rac-2,5-dibromohexanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl rac-2,5-dibromohexanedioate

There total 20 articles about dimethyl rac-2,5-dibromohexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethyl (2R,5S)-2,5-dibromohexanedioate (868-72-4,53490-47-4,124819-17-6) → dimethyl 2,5-dibromohexanedioate (868-72-4,53490-47-4,124819-17-6)

Guidance literature:

With potassium bromide; In N,N-dimethyl-formamide; at 80 ℃; for 2.3h;

DOI:10.1016/S0957-4166(02)00032-0

Reference yield: 88.0%

methanol (67-56-1) + Adipic acid (124-04-9) → dimethyl 2,5-dibromohexanedioate (868-72-4,53490-47-4,124819-17-6)

Guidance literature:

Adipic acid; With thionyl chloride; at 100 ℃; for 4h;

With bromine; at 20 - 100 ℃; for 22h;

methanol; Inert atmosphere;

DOI:10.1002/chem.201101427

Reference yield: 60.0%

methanol (67-56-1) + bromine (7726-95-6) + Adipic acid dichloride (111-50-2) → dimethyl rac-2,5-dibromohexanedioate (868-72-4,53490-47-4,124819-17-6)

Guidance literature:

methanol; bromine; Adipic acid dichloride; at 80 ℃; Inert atmosphere; Acidic conditions;

With potassium bromide; at 80 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1338865

upstream raw materials:

Adipic acid dichloride

methanol

Adipic acid

2,5-dibromohexanedioyl dichloride

Downstream raw materials:

cis-2,5-dicarbomethoxytetrahydrothiophene

dimethyl tetrahydrothiophene-2,5-dicarboxylate

1-<(S)-1-Phenylethyl>-2,5-(R,R)-bis(methoxycarbonyl)pyrrolidine

1-<(S)-1-Phenylethyl>-2,5-cis-bis(methoxycarbonyl)pyrrolidine