Technology Process of 2-<2-<2',3'-di(benzyloxy)benzyl>-4-isopropoxy-3-metoxy-5-methylphenyl>-4,4-dimethyl-2-oxazoline
There total 13 articles about 2-<2-<2',3'-di(benzyloxy)benzyl>-4-isopropoxy-3-metoxy-5-methylphenyl>-4,4-dimethyl-2-oxazoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1: 87 percent / potassium carbonate / dimethylformamide / 6 h / Ambient temperature
2: 92 percent / NaBH4, NaOH / methanol; H2O / 1 h / Heating
3: 89 percent / 1.) phosphorus tribromide, pyridine / CH2Cl2 / 0.67 h / Ambient temperature
4: 1.) butyllithium, 2.) copper(I) iodide triethyl phosphite
With
pyridine; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; triethylphosphite copper(I) iodide complex; phosphorus tribromide; potassium carbonate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / NaBH4, NaOH / methanol; H2O / 1 h / Heating
2: 89 percent / 1.) phosphorus tribromide, pyridine / CH2Cl2 / 0.67 h / Ambient temperature
3: 1.) butyllithium, 2.) copper(I) iodide triethyl phosphite
With
pyridine; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; triethylphosphite copper(I) iodide complex; phosphorus tribromide;
In
methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 80 percent / anhydrous potassium carbonate, potassium iodide / dimethylformamide / 15 h / 50 °C
2: 1.)hydrazine hydrate 2.)potassium hydroxide / 1.) diethylene glycol, 100 deg C, 0.5 h, 2.) reflux, 1.5 h
3: 87 percent / N,N-dimethylformamide / 2 h / Heating
4: 85 percent / sodium hydroxide / methanol; H2O / 72 h / Heating
5: 90 percent / thionyl chloride / 24 h / Ambient temperature
6: 90 percent / CH2Cl2 / 2.5 h / Ambient temperature
7: 90 percent / thionyl chloride / 0.05 h
8: 1.) butyllithium, 2.) copper(I) iodide triethyl phosphite
With
potassium hydroxide; sodium hydroxide; n-butyllithium; thionyl chloride; triethylphosphite copper(I) iodide complex; potassium carbonate; hydrazine hydrate; N,N-dimethyl-formamide; potassium iodide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
