Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl-

Base Information

Chemical Name:Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl-
CAS No.:158234-40-3
Molecular Formula:C₂₂H₂₄FNO₄
Molecular Weight:385.435
Hs Code.:
UNII:Q3DW13IZ8V
Nikkaji Number:J1.402.290B
Wikidata:Q27286958

Synonyms:AHL-157;UNII-Q3DW13IZ8V;158234-40-3;Q3DW13IZ8V;Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl-;SCHEMBL7814100;AKOS040750216;Q27286958;2-[3-[1-(4-fluorobenzoyl)piperidin-4-yl]phenoxy]-2-methylpropanoic acid

Suppliers and Price of Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl-

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:385.16893641
Heavy Atom Count:28
Complexity:551

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C(=O)O)OC1=CC=CC(=C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)F

Technology Process of Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl-

There total 7 articles about Propanoic acid, 2-(3-(1-(4-fluorobenzoyl)-4-piperidinyl)phenoxy)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{3-[1-(4-fluoro-benzoyl)-piperidin-4-yl]-phenoxy}-2-methyl-propionic acid ethyl ester

: 158234-40-3
AHL-157

Guidance literature:: With sodium hydroxide; In chloroform; acetone; at 35 ℃; for 1h;
DOI:10.1248/cpb.48.1978

Reference yield:

: 1-benzyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine hydrochloride

: 158234-40-3
AHL-157

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / 5 percent Pd/C / methanol; H₂O / 16 h / 20 °C / 760 Torr

2: 89 percent / 47 percent HBr / 2 h / Heating

3: 100 percent / aq. NaOH / propan-2-ol / 2 h / 40 - 50 °C

4: K₂CO₃ / 8 h / 100 °C

5: NaOH / acetone; CHCl₃ / 1 h / 35 °C

With sodium hydroxide; hydrogen bromide; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; chloroform; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.48.1978

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 158234-40-3
AHL-157

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaOH / propan-2-ol / 2 h / 40 - 50 °C

2: K₂CO₃ / 8 h / 100 °C

3: NaOH / acetone; CHCl₃ / 1 h / 35 °C

With sodium hydroxide; potassium carbonate; In chloroform; isopropyl alcohol; acetone;
DOI:10.1248/cpb.48.1978