(4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone

Base Information

Chemical Name:(4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone
CAS No.:325808-21-7
Molecular Formula:C₁₈H₁₈FNO₂
Molecular Weight:299.345
Hs Code.:
DSSTox Substance ID:DTXSID101184785

Synonyms:DTXSID101184785;(4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone;325808-21-7

Suppliers and Price of (4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:299.13215698
Heavy Atom Count:22
Complexity:373

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1C2=CC(=CC=C2)O)C(=O)C3=CC=C(C=C3)F

Technology Process of (4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone

There total 3 articles about (4-Fluorophenyl)[4-(3-hydroxyphenyl)-1-piperidinyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 403-43-0
4-fluorobenzoyl chloride

: 110878-71-2
4-(3-hydroxyphenyl)piperidine

: 325808-21-7
1-(4-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine

Guidance literature:: With sodium hydroxide; In isopropyl alcohol; at 40 - 50 ℃; for 2h;
DOI:10.1248/cpb.48.1978

Reference yield:

: 1-benzyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine hydrochloride

: 325808-21-7
1-(4-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 5 percent Pd/C / methanol; H₂O / 16 h / 20 °C / 760 Torr

2: 89 percent / 47 percent HBr / 2 h / Heating

3: 100 percent / aq. NaOH / propan-2-ol / 2 h / 40 - 50 °C

With sodium hydroxide; hydrogen bromide; hydrogen; palladium on activated charcoal; In methanol; water; isopropyl alcohol;
DOI:10.1248/cpb.48.1978

Reference yield:

: 325808-20-6
4-(3-methoxyphenyl)piperidine hydrogen chloride salt

: 325808-21-7
1-(4-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 47 percent HBr / 2 h / Heating

2: 100 percent / aq. NaOH / propan-2-ol / 2 h / 40 - 50 °C

With sodium hydroxide; hydrogen bromide; In isopropyl alcohol;
DOI:10.1248/cpb.48.1978