Technology Process of 3-(1-phenylethoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
There total 9 articles about 3-(1-phenylethoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 6.14 g / aq. NaHCO3 / acetone
2.1: NaH / dimethylformamide / 1 h / 20 °C
2.2: 85 percent / dimethylformamide / 24 h / 25 °C
3.1: 73 percent / ICl; NaN3 / acetonitrile; dimethylformamide / 70 h / Heating
4.1: 91 percent / toluene / 1 h
With
sodium azide; Iodine monochloride; sodium hydride; sodium hydrogencarbonate;
In
N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1039/b405768f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / Heating
1.2: MeOH / 0.75 h / Heating
2.1: 6.14 g / aq. NaHCO3 / acetone
3.1: NaH / dimethylformamide / 1 h / 20 °C
3.2: 85 percent / dimethylformamide / 24 h / 25 °C
4.1: 73 percent / ICl; NaN3 / acetonitrile; dimethylformamide / 70 h / Heating
5.1: 91 percent / toluene / 1 h
With
sodium azide; carbonochloridic acid 1-chloro-ethyl ester; Iodine monochloride; sodium hydride; sodium hydrogencarbonate;
In
1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1039/b405768f
