(2R,3S)-2-ethyl-3-methylpentanoic acid ((1'S,2'S)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide

Base Information

• Chemical Name: (2R,3S)-2-ethyl-3-methylpentanoic acid ((1'S,2'S)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide
• CAS No.: 1122577-97-2
• Molecular Formula: C₁₈H₂₉NO₂
• Molecular Weight: 291.434
• Mol file: 1122577-97-2.mol

Synonyms:

Chemical Property of (2R,3S)-2-ethyl-3-methylpentanoic acid ((1'S,2'S)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-ethyl-3-methylpentanoic acid ((1'S,2'S)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide

There total 1 articles about (2R,3S)-2-ethyl-3-methylpentanoic acid ((1'S,2'S)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pseudoephedrine (90-82-4,7009-81-6,90-83-5,6912-63-6) + pivaloyl chloride (3282-30-2) + (2S,3S)-2-ethyl-3-methyl valeric acid (210537-43-2) → (2R,3S)-2-ethyl-3-methylpentanoic acid ((1'S,2'S)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide (1122577-97-2) + (1S,2S)-1-Phenyl-2-(methylpivaloylamino)propanol

Guidance literature:

pivaloyl chloride; (2S,3S)-2-ethyl-3-methyl valeric acid; With triethylamine; In dichloromethane; at -5 - 0 ℃; Inert atmosphere;

pseudoephedrine; With triethylamine; In dichloromethane; at 5 ℃; Inert atmosphere;

DOI:10.1021/op800260j

upstream raw materials:

pseudoephedrine

pivaloyl chloride

(2S,3S)-2-ethyl-3-methyl valeric acid