C₂₃H₁₇F₅N₄O₂

Base Information

• Chemical Name: C₂₃H₁₇F₅N₄O₂
• CAS No.: 1276039-33-8
• Molecular Formula: C₂₃H₁₇F₅N₄O₂
• Molecular Weight: 476.406
• Mol file: 1276039-33-8.mol

Synonyms:

Chemical Property of C₂₃H₁₇F₅N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₁₇F₅N₄O₂

There total 7 articles about C₂₃H₁₇F₅N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

C21H11F6N3O2 (1276034-22-0) + dimethyl amine (124-40-3) → C23H17F5N4O2 (1276039-33-8)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2013.05.037

Reference yield:

5-(benzyloxy)-4-fluoro-2-nitrobenzoic acid (1113049-59-4) → C23H17F5N4O2 (1276039-33-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / Reflux

1.2: 20 °C / 760.05 Torr

2.1: sodium cyanoborohydride; acetic acid / 50 °C

3.1: caesium carbonate / acetonitrile / 80 °C

4.1: sodium hydroxide / dimethyl sulfoxide

5.1: trifluoroacetic acid

6.1: triethylamine / tetrahydrofuran

With sulfuric acid; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.bmcl.2013.05.037

Reference yield:

methyl 2-amino-4-fluoro-5-hydroxybenzoate (1113049-61-8) → C23H17F5N4O2 (1276039-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / 50 °C

2: caesium carbonate / acetonitrile / 80 °C

3: sodium hydroxide / dimethyl sulfoxide

4: trifluoroacetic acid

5: triethylamine / tetrahydrofuran

With sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.bmcl.2013.05.037

upstream raw materials:

4,5-difluoro-2-nitrobenzoic acid

C₂₁H₁₁F₆N₃O₂

dimethyl amine

5-(benzyloxy)-4-fluoro-2-nitrobenzoic acid