2,6-Piperidinedione, 4,4-dimethyl-1-(phenylmethyl)-

Base Information

• Chemical Name: 2,6-Piperidinedione, 4,4-dimethyl-1-(phenylmethyl)-
• CAS No.: 106754-11-4
• Molecular Formula: C14H17NO2
• Molecular Weight: 231.294
• ChEMBL ID: CHEMBL1594470
• DSSTox Substance ID: DTXSID20403054
• Wikidata: Q82206594
• Mol file: 106754-11-4.mol

Synonyms:106754-11-4;1-benzyl-4,4-dimethylpiperidine-2,6-dione;2,6-Piperidinedione, 4,4-dimethyl-1-(phenylmethyl)-;MLS000699109;SCHEMBL1352319;CHEMBL1594470;DTXSID20403054;ZQADGHDZWLYXBI-UHFFFAOYSA-N;HMS2613P23;SMR000226941;1-benzyl-4,4-dimethyl-2,6-piperidinedione;F94674

Chemical Property of 2,6-Piperidinedione, 4,4-dimethyl-1-(phenylmethyl)-

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 231.125928785
• Heavy Atom Count: 17
• Complexity: 296

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(=O)N(C(=O)C1)CC2=CC=CC=C2)C

Technology Process of 2,6-Piperidinedione, 4,4-dimethyl-1-(phenylmethyl)-

There total 3 articles about 2,6-Piperidinedione, 4,4-dimethyl-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,3-dimethyl glutarimide (1123-40-6) + benzyl bromide (100-39-0) → 1-benzyl-4,4-dimethylpiperidine-2,6-dione (106754-11-4)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃; for 4h;

Reference yield:

4-Benzylcarbamoyl-3,3-dimethyl-butyric acid (106754-08-9) → 1-benzyl-4,4-dimethylpiperidine-2,6-dione (106754-11-4)

Guidance literature:

With pyridine; dmap; N,N’-disuccinimidyl oxalate; Yield given. Multistep reaction; 1.) acetonitrile, 2 h, 25 grad C, 2.) trichloroethylene, reflux, 5 h;

DOI:10.1016/S0040-4039(00)84137-4

Reference yield:

diethyl 3,3-dimethylglutarate (17804-59-0) + benzylamine (100-46-9) → 1-benzyl-4,4-dimethylpiperidine-2,6-dione (106754-11-4)

Guidance literature:

4 Mol Benzylamin unter 125 at Wasserstoff-Druck auf 250grad;

upstream raw materials:

4-Benzylcarbamoyl-3,3-dimethyl-butyric acid

diethyl 3,3-dimethylglutarate

benzylamine

3,3-dimethyl glutarimide

Downstream raw materials:

4,4-dimethylpiperidine

(E)-1-benzyl-4,4-dimethylpiperidine-2,3,6-trione 3-oxime

(Z)-1-benzyl-3-(hydroxyimino)-4,4-dimethylpiperidine-2,6-dione

1-benzyl-4,4-dimethylpiperidin-3-amine