[4-(3-Bromopropoxy)-3-methoxyphenyl]methanol

Base Information

• Chemical Name: [4-(3-Bromopropoxy)-3-methoxyphenyl]methanol
• CAS No.: 110316-11-5
• Molecular Formula: C11H15BrO3
• Molecular Weight: 275.142
• DSSTox Substance ID: DTXSID10552227
• Wikidata: Q82432327
• Mol file: 110316-11-5.mol

Synonyms:110316-11-5;[4-(3-BROMOPROPOXY)-3-METHOXYPHENYL]METHANOL;DTXSID10552227

Chemical Property of [4-(3-Bromopropoxy)-3-methoxyphenyl]methanol

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 274.02046
• Heavy Atom Count: 15
• Complexity: 166

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)CO)OCCCBr

Technology Process of [4-(3-Bromopropoxy)-3-methoxyphenyl]methanol

There total 4 articles about [4-(3-Bromopropoxy)-3-methoxyphenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(3-bromopropoxy)-3-methoxybenzaldehyde (148433-00-5) → 4-(3-bromopropoxy)-3-methoxyphenyl methanol (110316-11-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 ℃; for 6h;

DOI:10.3184/030823408X324724

Reference yield: 60.0%

4-hydroxymethyl-2-methoxyphenol (498-00-0) + 1,3-dibromo-propane (109-64-8) → 4-(3-bromopropoxy)-3-methoxyphenyl methanol (110316-11-5) + 1,3-bis<4-(hydroxymethyl)-2-methoxyphenoxy>propane (110316-12-6)

Guidance literature:

With potassium carbonate; In acetone; for 15h; Heating;

DOI:10.1021/ja00255a035

Reference yield:

ethylene dibromide (106-93-4) + (3,4-dimethoxyphenyl)methanol (93-03-8) → 4-(3-bromopropoxy)-3-methoxyphenyl methanol (110316-11-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Yield given; Heating;

DOI:10.1016/S0040-4039(00)78271-2

upstream raw materials:

ethylene dibromide

(3,4-dimethoxyphenyl)methanol

4-hydroxymethyl-2-methoxyphenol

1,3-dibromo-propane

Downstream raw materials:

2-[4-(3-bromopropoxy)-3-methoxybenzyloxy]tetrahydropyran

C₁₀₂H₁₃₂O₁₅

cryptophane-E

{3-methoxy-4-[2-(3,8,13-trimethoxy-7,12-bis{3-[2-methoxy-4-(tetrahydropyran-2-yloxymethyl)phenoxy]propoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yloxy)ethoxy]phenyl}methanol