Ethyl 9H-fluorene-9-carboxylate

Base Information

• Chemical Name: Ethyl 9H-fluorene-9-carboxylate
• CAS No.: 26878-12-6
• Molecular Formula: C16H14 O2
• Molecular Weight: 238.286
• Hs Code.: 2916399090
• European Community (EC) Number: 248-080-8
• DSSTox Substance ID: DTXSID001303508
• Nikkaji Number: J249.075G
• Mol file: 26878-12-6.mol

Synonyms:Ethyl 9H-fluorene-9-carboxylate;Ethyl fluorene-9-carboxylate;26878-12-6;EINECS 248-080-8;9-ethoxycarbonylfluorene;ethyl 9-fluorene carboxylate;SCHEMBL1419881;DTXSID001303508;Ethyl 9H-fluorene-9-carboxylate #;AKOS025132440;fluorene-9-carboxylic acid ethyl ester;9H-Fluorene-9-carboxylic acid ethyl ester;9H-Fluorene-9-carboxylic acid, ethyl ester

Chemical Property of Ethyl 9H-fluorene-9-carboxylate

Chemical Property:

• Vapor Pressure: 1.48E-05mmHg at 25°C
• Boiling Point: 366.3°Cat760mmHg
• Flash Point: 169.3°C
• PSA: 26.30000
• Density: 1.176g/cm³
• LogP: 3.36200
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 238.099379685
• Heavy Atom Count: 18
• Complexity: 290

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 9H-FLUORENE-9-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of Ethyl 9H-fluorene-9-carboxylate

There total 19 articles about Ethyl 9H-fluorene-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 9H-fluorene-9-carboxylic acid (1989-33-9) → ethyl fluorene-9-carboxylate (26878-12-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.7b11435

Reference yield:

ethanol (64-17-5) + ethyl 9-acetyl-9H-fluorene-9-carboxylate (861292-64-0) → ethyl fluorene-9-carboxylate (26878-12-6) + ethyl acetate (141-78-6)

Guidance literature:

at 120 ℃;

Reference yield:

9H-fluorene (86-73-7) + formic acid ethyl ester (109-94-4) → ethyl fluorene-9-carboxylate (26878-12-6)

Guidance literature:

9H-fluorene; With sodium hydride; In tetrahydrofuran; mineral oil; at 10 ℃; for 1h;

formic acid ethyl ester; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

upstream raw materials:

methanol

diethyl 9H-fluorene-9,9-dicarboxylate

sodium methylate

ethanol

Downstream raw materials:

9-(3-oxo-1-phenyl-3-[3]pyridyl-propyl)-fluorene-9-carboxylic acid ethyl ester

ethanol

9H-fluorene-9-carboxylic acid

9-hydroxy-9-fluorene carboxylic acid

Refernces

• 1、 -. "COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES". Paragraph 0067; 0068; 0069; 0070. . Retrieved 2013/03/26.
• 2、 -. "SPIROFLUORENEISOTHIAZOLIDINONE DIOXIDES AS ALDOSE REDUCTASE INHIBITORS". . . Retrieved 2008/06/13.