1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-phenyl-

Base Information

• Chemical Name: 1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-phenyl-
• CAS No.: 116557-89-2
• Molecular Formula: C15H13N3O
• Molecular Weight: 251.288
• Mol file: 116557-89-2.mol

Synonyms:

Chemical Property of 1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-phenyl-

There total 37 articles about 1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-methoxy-phenylazide (2101-87-3) + phenylacetylene (536-74-3) → 1-(4-methoxy-phenyl)-4-phenyl-1H-[1,2,3]triazole (116557-89-2)

Guidance literature:

With bis(triphenylphosphine)copper(I) nitrate; at 25 ℃; for 2h; Neat (no solvent);

DOI:10.1039/c0gc00381f

Reference yield: 98.0%

4-methoxy-aniline (104-94-9) + phenylacetylene (536-74-3) → 1-(4-methoxy-phenyl)-4-phenyl-1H-[1,2,3]triazole (116557-89-2)

Guidance literature:

4-methoxy-aniline; With hydrogenchloride; In water; at 0 - 5 ℃; for 0.0833333h;

With sodium nitrite; In water; at 0 - 5 ℃;

phenylacetylene; regioselective reaction; Further stages;

DOI:10.1039/c8nj00665b

Reference yield: 97.0%

4-methoxyphenylboronic acid (5720-07-0) + phenylacetylene (536-74-3) → 1-(4-methoxy-phenyl)-4-phenyl-1H-[1,2,3]triazole (116557-89-2)

Guidance literature:

With sodium azide; In water; at 20 ℃; for 3h;

DOI:10.1039/c6ra16646f

upstream raw materials:

p-methoxy-phenylazide

phenylacetylene

para-iodoanisole

1-bromo-4-methoxy-benzene

Downstream raw materials:

5-(3,5-di(methyloxycarbonyl)phenyl)-1-(4-methoxyphenyl)-4-phenyl-1H-1,2,3-triazole

1-(4-methoxyphenyl)-5-(4-methyloxycarbonylphenyl)-4-phenyl-1H-1,2,3-triazole

5-(3-(N,N-dimethylamino)phenyl)-1-(4-methoxyphenyl)-4-phenyl-1H-1,2,3-triazole

Refernces

• 1、 Chassaing, Stefan,Kumarraja, Mayilvasagam,Sido, Abdelkarim Sani Souna,Pale, Patrick,Sommer, Jean. "Click chemistry in CuI-zeolites: The Huisgen [3 + 2]-cycloaddition". . p. 883 - 886. Retrieved 2007.
• 2、 Andersen, Jacob,Bolvig, Simon,Liang, Xifu. "Efficient one-pot synthesis of 1-aryl 1,2,3-triazoles from aryl halides and terminal alkynes in the presence of sodium azide". . p. 2941 - 2947. Retrieved 2005.
• 3、 Souza, Jaqueline F.,Costa, Gabriel P.,Luque, Rafael,Alves, Diego,Fajardo, André R.. "Polysaccharide-based superporous hydrogel embedded with copper nanoparticles: A green and versatile catalyst for the synthesis of 1,2,3-triazoles". . p. 136 - 145. Retrieved 2019.
• 4、 Gajurel, Sushmita,Dam, Binoyargha,Bhushan, Mayank,Singh, L. Robindro,Pal, Amarta Kumar. "CuO–NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level". . . Retrieved 2021/12/09.
• 5、 Giofrè, Salvatore Vincenzo,Tiecco, Matteo,Ferlazzo, Angelo,Romeo, Roberto,Ciancaleoni, Gianluca,Germani, Raimondo,Iannazzo, Daniela. "Base-Free Copper-Catalyzed Azide-Alkyne Click Cycloadditions (CuAAc) in Natural Deep Eutectic Solvents as Green and Catalytic Reaction Media**". . p. 4777 - 4789. Retrieved 2021/08/30.