Azido-PEG8-t-butyl ester

Base Information

• Chemical Name: Azido-PEG8-t-butyl ester
• CAS No.: 1623791-99-0
• Molecular Formula: C₂₃H₄₅N₃O₁₀
• Molecular Weight: 523.624
• Mol file: 1623791-99-0.mol

Synonyms:

Chemical Property of Azido-PEG8-t-butyl ester

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

N3-PEG8-CH2CH2COOtBu min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG8-t-butyl ester is a click chemistry compound conpprising an azide group and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Technology Process of Azido-PEG8-t-butyl ester

There total 5 articles about Azido-PEG8-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C30H52O13S (1345337-28-1) → C23H45N3O10 (1623791-99-0)

Guidance literature:

With sodium azide; In acetone; for 16h; Inert atmosphere; Reflux;

DOI:10.1039/c4nj00654b

Reference yield: 98.54%

C24H48O13S → C23H45N3O10 (1623791-99-0)

Guidance literature:

With sodium azide; sodium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 12h;

Reference yield:

tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (1334177-84-2) → C23H45N3O10 (1623791-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: sodium azide / acetone / 16 h / Inert atmosphere; Reflux

With sodium azide; triethylamine; In dichloromethane; acetone;

DOI:10.1039/c4nj00654b

upstream raw materials:

tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

C₃₀H₅₂O₁₃S

octaethylene glycol

tert-Butyl acrylate

Downstream raw materials:

27-azido-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid

Refernces

• 1、 Garofalo, Antonio,Parat, Audrey,Bordeianu, Catalina,Ghobril, Cynthia,Kueny-Stotz, Marie,Walter, Aurlie,Jouhannaud, Julien,Begin-Colin, Sylvie,Felder-Flesch, Delphine. "Efficient synthesis of small-sized phosphonated dendrons: Potential organic coatings of iron oxide nanoparticles". . p. 5226 - 5239. Retrieved 2014/12/10.