1H-Pyrazole-3-carboxylic acid, 1,5-bis(4-methoxyphenyl)-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-3-carboxylic acid, 1,5-bis(4-methoxyphenyl)-, ethyl ester
CAS No.:119517-21-4
Molecular Formula:C20H20N2O4
Molecular Weight:352.39
Hs Code.:
DSSTox Substance ID:DTXSID60566793
Nikkaji Number:J258.169H
Wikidata:Q82452551
Mol file:119517-21-4.mol

Synonyms:119517-21-4;1H-Pyrazole-3-carboxylic acid, 1,5-bis(4-methoxyphenyl)-, ethyl ester;SCHEMBL9054421;DTXSID60566793;AIOKIAZWWNBJMD-UHFFFAOYSA-N;ETHYL 1,5-BIS(4-METHOXYPHENYL)PYRAZOLE-3-CARBOXYLATE;ethyl 1,5-bis (4-methoxyphenyl)pyrazole-3-carboxylate;Ethyl 1,5-bis(4-methoxyphenyl)-1H-pyrazole-3-carboxylate

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-3-carboxylic acid, 1,5-bis(4-methoxyphenyl)-, ethyl ester

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:352.14230712
Heavy Atom Count:26
Complexity:445

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=NN(C(=C1)C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

Technology Process of 1H-Pyrazole-3-carboxylic acid, 1,5-bis(4-methoxyphenyl)-, ethyl ester

There total 7 articles about 1H-Pyrazole-3-carboxylic acid, 1,5-bis(4-methoxyphenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: lithium ethyl 4-methoxybenzoylpyruvate

: 119517-21-4
ethyl 1,5-bis (4-methoxyphenyl)pyrazole-3-carboxylate

: 126839-74-5
2,5-Bis-(4-methoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: In ethanol; for 16h; Yields of byproduct given;

Reference yield: 47.0%

: 1448157-84-3
4-(4-methoxyphenyl)-3-(methoxyphenyl)sydnone

: 623-47-2
propynoic acid ethyl ester

: C₂₀H₂₀N₂O₄

: 119517-21-4
ethyl 1,5-bis (4-methoxyphenyl)pyrazole-3-carboxylate

Guidance literature:: In 1,2-dichloro-benzene; at 140 - 180 ℃; for 16h; Overall yield = < 60 %;
DOI:10.1021/acs.joc.5b00143

Reference yield:

: 95-92-1
oxalic acid diethyl ester

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 3471-32-7
4-Methoxyphenylhydrazine

: 119517-21-4
ethyl 1,5-bis (4-methoxyphenyl)pyrazole-3-carboxylate

: 126839-74-5
2,5-Bis-(4-methoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: oxalic acid diethyl ester; 1-(4-methoxyphenyl)ethanone; With lithium hexamethyldisilazane; In diethyl ether;

4-Methoxyphenylhydrazine; With toluene-4-sulfonic acid; In tetrahydrofuran; at 40 ℃;
DOI:10.1016/j.bmcl.2005.09.048