p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester

Base Information

• Chemical Name: p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester
• CAS No.: 225650-64-6
• Molecular Formula: C₂₄H₂₇NO₈
• Molecular Weight: 457.48
• Mol file: 225650-64-6.mol

Synonyms:

Chemical Property of p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester

There total 5 articles about p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Hydroxy-2-coumaranone (2688-48-4) → p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester (225650-64-6)

Guidance literature:

Multi-step reaction with 5 steps

1: buffer / acetonitrile; H₂O / 6 h / pH 8

2: p-TsOH / 4 h / Heating

3: p-TsOH / 4 h / 20 °C

4: NaOH / methanol

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl / pyridine / 36 h

With sodium hydroxide; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; methanol; water; acetonitrile; 1: Hydrolysis / 2: Esterification / 3: Addition / 4: Hydrolysis / 5: Esterification;

DOI:10.1021/ac981236c

Reference yield:

homogentisic acid (451-13-8) → p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester (225650-64-6)

Guidance literature:

Multi-step reaction with 4 steps

1: p-TsOH / 4 h / Heating

2: p-TsOH / 4 h / 20 °C

3: NaOH / methanol

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl / pyridine / 36 h

With sodium hydroxide; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; methanol; 1: Esterification / 2: Addition / 3: Hydrolysis / 4: Esterification;

DOI:10.1021/ac981236c

Reference yield:

methyl (2,5-dihydroxyphenyl)acetate (60508-85-2) → p-nitrophenyl 2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ester (225650-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH / 4 h / 20 °C

2: NaOH / methanol

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl / pyridine / 36 h

With sodium hydroxide; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; methanol; 1: Addition / 2: Hydrolysis / 3: Esterification;

DOI:10.1021/ac981236c

upstream raw materials:

4-nitro-phenol

2,5-dihydroxyphenylacetic acid bis-tetrahydropyranyl ester

5-Hydroxy-2-coumaranone

homogentisic acid