7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-5-hydroxy-6-phenyl-

Base Information

• Chemical Name: 7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-5-hydroxy-6-phenyl-
• CAS No.: 122706-49-4
• Molecular Formula: C13H10N2O2
• Molecular Weight: 226.235
• DSSTox Substance ID: DTXSID20434186
• Nikkaji Number: J3.015.556D
• Mol file: 122706-49-4.mol

Synonyms:122706-49-4;5-Hydroxy-6-phenyl-5H-pyrrolo[3,4-b]pyridin-7(6H)-one;7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-5-hydroxy-6-phenyl-;SCHEMBL8803517;DTXSID20434186;CBLVQROEGOSBJR-UHFFFAOYSA-N;5-Hydroxy-6-phenyl-5H-pyrrolo[3,4-b]pyridine-7(6H)-one;5,6-Dihydro-5-hydroxy-6-phenyl-7H-pyrrolo-[3,4-b]pyridin-7-one;5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo[3,4-b]pyridin-7-one

Chemical Property of 7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-5-hydroxy-6-phenyl-

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 226.074227566
• Heavy Atom Count: 17
• Complexity: 302

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C(C3=C(C2=O)N=CC=C3)O

Technology Process of 7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-5-hydroxy-6-phenyl-

There total 9 articles about 7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-5-hydroxy-6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2tmosphere + N-phenylpicolinamide (10354-53-7) + Methyl formate (107-31-3) → 5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo<3,4-b>pyridin-7-one (122706-49-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

N-phenylpicolinamide (10354-53-7) + Methyl formate (107-31-3) → 5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo<3,4-b>pyridin-7-one (122706-49-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

6-Phenylpyrrolo<3,4-b>pyridine-5,7(6H)-dione (6538-81-4) → 5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo<3,4-b>pyridin-7-one (122706-49-4) + 6,7-dihydro-7-hydroxy-6-phenyl-5H-pyrrolo<3,4-b>pyridin-5-one (122706-33-6)

Guidance literature:

With sodium tetrahydroborate; magnesium(II) perchlorate; In methanol; chloroform; at 0 ℃; for 0.25h; Yield given. Yields of byproduct given;

DOI:10.1246/bcsj.62.1205

upstream raw materials:

N-phenylpicolinamide

N,N-dimethyl-formamide

6-Phenylpyrrolo<3,4-b>pyridine-5,7(6H)-dione

Pyridine-2,3-dicarboxylic anhydride

Downstream raw materials:

methyl 3-(1',1'-dimethoxymethyl)pyridine-2-carboxylate

(3-Hydroxymethyl-pyridin-2-yl)-(2-methoxy-phenyl)-methanone

pyrido[2,3-d]pyridazin-8(7H)-one

phenyl 3-hydroxymethylpicolinanilide