5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)
CAS No.:158852-07-4
Molecular Formula:C₅₂H₆₂N₃O₈PSi
Molecular Weight:916.139
Hs Code.:

Synonyms:

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104655-84-7
5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite

: 40438-48-0
diphenylmethylsilylethylethanol

: 158852-07-4,155398-46-2,155398-47-3
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃; for 12h;

Reference yield:

: 40438-48-0
diphenylmethylsilylethylethanol

: 158852-07-4,155398-46-2,155398-47-3
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₃ / diethyl ether / 2 h / Ambient temperature

2: diethyl ether / 24 h / Ambient temperature

3: 1.) 1H-tetrazol, 1.) Et₃N / 1.) MeCN, 20 min; 3 h, 2.) -20 deg C, 12 h

With 1H-tetrazole; triethylamine; phosphorus trichloride; In diethyl ether;

Reference yield:

: 289698-26-6
C₁₅H₁₇Cl₂OPSi

: 158852-07-4,155398-46-2,155398-47-3
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite)

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 24 h / Ambient temperature

2: 1.) 1H-tetrazol, 1.) Et₃N / 1.) MeCN, 20 min; 3 h, 2.) -20 deg C, 12 h

With 1H-tetrazole; triethylamine; In diethyl ether;