Pyrrolo[3,2,1-jk][1,4]benzodiazepine-7(1H)-acetic acid, 2-[(1,1-dimethylethoxy)carbonyl]-3,4-dihydro-Alpha-oxo-, methyl ester

Base Information

Chemical Name:Pyrrolo[3,2,1-jk][1,4]benzodiazepine-7(1H)-acetic acid, 2-[(1,1-dimethylethoxy)carbonyl]-3,4-dihydro-Alpha-oxo-, methyl ester
CAS No.:345264-16-6
Molecular Formula:C₁₉H₂₂N₂O₅
Molecular Weight:358.394
Hs Code.:
Mol file:345264-16-6.mol

Synonyms:

Suppliers and Price of Pyrrolo[3,2,1-jk][1,4]benzodiazepine-7(1H)-acetic acid, 2-[(1,1-dimethylethoxy)carbonyl]-3,4-dihydro-Alpha-oxo-, methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolo[3,2,1-jk][1,4]benzodiazepine-7(1H)-acetic acid, 2-[(1,1-dimethylethoxy)carbonyl]-3,4-dihydro-Alpha-oxo-, methyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of Pyrrolo[3,2,1-jk][1,4]benzodiazepine-7(1H)-acetic acid, 2-[(1,1-dimethylethoxy)carbonyl]-3,4-dihydro-Alpha-oxo-, methyl ester

There total 7 articles about Pyrrolo[3,2,1-jk][1,4]benzodiazepine-7(1H)-acetic acid, 2-[(1,1-dimethylethoxy)carbonyl]-3,4-dihydro-Alpha-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 79-37-8
oxalyl dichloride

: 124-41-4
sodium methylate

: 345264-15-5
S-6-(tert-butoxycarbonyl)-5,6-dihydro-6H-[1,4]diazepino[6,7,1-hi]indole

: 345264-16-6
(6-(tert-butoxycarbonyl)-5,6-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)oxoacetic acid methyl ester

Guidance literature:: In dichloromethane;
DOI:10.1016/j.bmcl.2004.05.088

Reference yield:

: 1074-88-0
1H-indole-7-carbaldehyde

: 345264-16-6
(6-(tert-butoxycarbonyl)-5,6-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)oxoacetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/c / methanol / 20 °C / 760 Torr

2.1: aq. K₂CO₃ / tetrahydrofuran / 0 °C

3.1: Et₃N / tetrahydrofuran / 2 h / 0 °C

4.1: NaH / dimethylformamide / 0 °C

5.1: CH₂Cl₂ / 0 °C

5.2: methanol; CH₂Cl₂ / -78 - 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049768a

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 345264-16-6
(6-(tert-butoxycarbonyl)-5,6-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)oxoacetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. K₂CO₃ / tetrahydrofuran / 0 °C

2.1: Et₃N / tetrahydrofuran / 2 h / 0 °C

3.1: NaH / dimethylformamide / 0 °C

4.1: CH₂Cl₂ / 0 °C

4.2: methanol; CH₂Cl₂ / -78 - 20 °C

With sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049768a