N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

Base Information

Chemical Name:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide
CAS No.:1361970-55-9
Molecular Formula:C₃₀H₃₂N₆O₇S₂
Molecular Weight:652.752
Hs Code.:

N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

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Chemical Property of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

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Technology Process of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

There total 16 articles about N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1083326-75-3
N-[2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]methanesulfonamide

: 1254036-85-5,1364801-65-9
6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

: 1361970-55-9,1364802-69-6
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

Guidance literature:: With potassium dihydrogenphosphate; potassium hydrogen bifluoride; palladium diacetate; tricyclohexylphosphine; In water; isopropyl alcohol; at 80 ℃; for 2.5h;
DOI:10.1021/acs.oprd.8b00006

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1361970-55-9,1364802-69-6
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 2.75 h / 0 - 10 °C / Industry scale; Inert atmosphere

2.1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere

3.1: pyridine / acetonitrile / 3 h / 15 - 25 °C / Industry scale; Inert atmosphere

4.1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 14.5 h / 90 - 100 °C / Inert atmosphere

4.2: 1 h

5.1: sodium hydrogencarbonate / tricyclohexylphosphine; palladium diacetate / isopropyl alcohol; water / 2.5 h / 60 - 65 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium acetate; iron; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; tricyclohexylphosphine; In 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1254036-85-5,1364801-65-9
6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

: 1361970-56-0
potassium {6-(methoxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}trifluoroborate

: 1361970-55-9,1364802-69-6
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

Guidance literature:: With sodium hydrogencarbonate; palladium diacetate; tricyclohexylphosphine; In water; isopropyl alcohol; at 60 - 65 ℃; for 2.5h; Inert atmosphere;