4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole

Base Information

Chemical Name:4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole
CAS No.:1310146-40-7
Molecular Formula:C₄₂H₄₂N₄O₅
Molecular Weight:682.819
Hs Code.:

Synonyms:

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Chemical Property of 4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole

Chemical Property:

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Technology Process of 4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole

There total 18 articles about 4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246523-44-3
2-azido-1-tert-butoxy-3-iodobenzene

: 1310146-39-4
6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1310146-40-7
4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1.5h;
DOI:10.1002/asia.201000544

Reference yield:

: 1246523-50-1
4-bromo-6-methoxy-3,7-bis-(4-methoxy-phenyl)-2,3-dihydro-1H-indole

: 1310146-40-7
4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 1 h / 20 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 2 h

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 1.5 h / Reflux

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / 1,4-dioxane; water / 1.5 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 4.1: Suzuki-Miyaura coupling;
DOI:10.1002/asia.201000544

Reference yield:

: 1246523-54-5
tert-butyl [2-(tert-butoxy)phenyl]carbamate

: 1310146-40-7
4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 3.58 h / -78 - -20 °C

1.2: 3.3 h / -100 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C

2.2: 0 °C

3.1: acetic acid; sodium nitrite / water; acetonitrile / 0 °C

3.2: 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / 1,4-dioxane; water / 1.5 h / 20 °C

With 2,6-dimethylpyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tert.-butyl lithium; acetic acid; sodium hydroxide; sodium nitrite; In 1,4-dioxane; diethyl ether; dichloromethane; water; acetonitrile; pentane; 4.1: Suzuki-Miyaura coupling;
DOI:10.1002/asia.201000544