Technology Process of 6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
There total 11 articles about 6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 1 h / 20 °C
2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C
2.2: 2 h
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 1.5 h / Reflux
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide;
In
1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/asia.201000544
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 2 h
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 1.5 h / Reflux
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; potassium hydroxide;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/asia.201000544
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Mg(TMP)2*2LiBr / tetrahydrofuran / 1.25 h / -78 - 0 °C
1.2: 1.17 h / -78 °C
1.3: 1.5 h / 20 °C
2.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C
2.2: 0 °C
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 1 h / 20 °C
4.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C
4.2: 2 h
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 1.5 h / Reflux
With
2,6-dimethylpyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; Mg(TMP)2*2LiBr; potassium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/asia.201000544
