(2-Fluorophenyl)(4-fluorophenyl)(phenyl)methanol

Base Information

• Chemical Name: (2-Fluorophenyl)(4-fluorophenyl)(phenyl)methanol
• CAS No.: 128092-72-8
• Molecular Formula: C19H14F2O
• Molecular Weight: 296.316
• UNII: JLU7MHV7FP
• Mol file: 128092-72-8.mol

Synonyms:(2-Fluorophenyl)(4-fluorophenyl)(phenyl)methanol;128092-72-8;Flutrimazole carbinol;(2-fluorophenyl)-(4-fluorophenyl)-phenylmethanol;Benzenemethanol, 2-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-;JLU7MHV7FP;SCHEMBL1443904;C19H14F2O;OBUSEBRACGMKSM-UHFFFAOYSA-N;MFCD25977181;Flutrimazole Impurity B [EP Impurity];BS-50673;SY039732;CS-0085458;(2-Fluorophenyl)(4-fluorophenyl)phenylmethanol;Y11163;(2-Fluorophenyl)-(4-fluorophenyl)phenylmethanol;(2-fluorophenyl)-(4-fluorophenyl) phenylmethanol;A921457;(RS)-(2-fluorophenyl)(4-fluorophenyl)phenylmethanol;2-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzenemethanol

Chemical Property of (2-Fluorophenyl)(4-fluorophenyl)(phenyl)methanol

Chemical Property:

• Melting Point: 86.4-86.8℃
• Boiling Point: 420.3±40.0 °C(Predicted)
• PSA: 20.23000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 4.24900
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 296.10127139
• Heavy Atom Count: 22
• Complexity: 347

Purity/Quality:

97% ^*data from raw suppliers

Flutrimazole impurity B European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)O

Technology Process of (2-Fluorophenyl)(4-fluorophenyl)(phenyl)methanol

There total 3 articles about (2-Fluorophenyl)(4-fluorophenyl)(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4'-difluorobenzophenone (342-25-6) + phenylmagnesium bromide (100-58-3) → (2-fluorophenyl)-(4-fluorophenyl)phenylmethanol (128092-72-8)

Guidance literature:

In tert-butylmethyl ether;

Reference yield:

2,4'-difluorobenzophenone (342-25-6) + phenylmagnesium bromide → (2-fluorophenyl)-(4-fluorophenyl)phenylmethanol (128092-72-8)

Guidance literature:

2,4'-difluorobenzophenone; phenylmagnesium bromide; In various solvent(s); for 3h; Heating;

With hydrogenchloride; at 0 ℃; Further stages.;

DOI:10.1021/jm070663s

Reference yield:

o-fluorobenzophenone (342-24-5) + 1-Bromo-4-fluorobenzene (460-00-4) → (2-fluorophenyl)-(4-fluorophenyl)phenylmethanol (128092-72-8)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h;

upstream raw materials:

o-fluorobenzophenone

1-Bromo-4-fluorobenzene

2,4'-difluorobenzophenone

phenylmagnesium bromide

Downstream raw materials:

(2-fluorophenyl)-(4-fluorophenyl)phenylchloromethane

flutrimazole