(1R,2R)-2-(Phenylmethyl)cyclopropanol

Base Information

Chemical Name:(1R,2R)-2-(Phenylmethyl)cyclopropanol
CAS No.:129423-31-0
Molecular Formula:C₁₀H₁₂O
Molecular Weight:148.205
Hs Code.:
DSSTox Substance ID:DTXSID301287646
Nikkaji Number:J337.783K

Synonyms:DTXSID301287646;(1R,2R)-2-(Phenylmethyl)cyclopropanol;129423-31-0

Suppliers and Price of (1R,2R)-2-(Phenylmethyl)cyclopropanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of (1R,2R)-2-(Phenylmethyl)cyclopropanol

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:148.088815002
Heavy Atom Count:11
Complexity:127

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C1O)CC2=CC=CC=C2
Isomeric SMILES:C1[C@H]([C@@H]1O)CC2=CC=CC=C2

Technology Process of (1R,2R)-2-(Phenylmethyl)cyclopropanol

There total 7 articles about (1R,2R)-2-(Phenylmethyl)cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1462-75-5
3-phenylpropylmagnesium bromide

: 109-94-4
formic acid ethyl ester

: 129423-31-0,148555-74-2
trans-2-benzylcyclopropanol

Guidance literature:: formic acid ethyl ester; With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; for 0.0833333h; Cooling with ice; Inert atmosphere;

3-phenylpropylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.9b01616

Reference yield:

: 19261-37-1
2-chloro-3-phenyl-propionaldehyde

: 31729-70-1
bis(iodozinc)methane

: 129423-31-0,148555-74-2
trans-2-benzylcyclopropanol

: cis-2-benzylcyclopropanol

Guidance literature:: In tetrahydrofuran; at 0 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol200597h

Reference yield:

: 122-97-4
3-Phenyl-1-propanol

: 129423-31-0,148555-74-2
(1S,2S)-2-Benzyl-cyclopropanol

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid / dichloromethane / 3 h / 0 - 20 °C

2: tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere

3: Chiralpak AD / methanol; acetonitrile / Resolution of racemate

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jacs.7b07104