1-Methyl-2-propylpiperidine

Base Information

• Chemical Name: 1-Methyl-2-propylpiperidine
• CAS No.: 125133-94-0
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.257
• NSC Number: 363749
• UNII: Z2XXC13FWM
• DSSTox Substance ID: DTXSID901310152
• Nikkaji Number: J1.077.262A
• Wikipedia: N-Methylconiine
• Wikidata: Q1213574
• Mol file: 125133-94-0.mol

Synonyms:1-methyl-2-propylpiperidine;125133-94-0;(+/-)-N-Methylconiine;Z2XXC13FWM;Methylconiine, (+/-)-;2-Propyl-1-methylpiperidine;Methylconiine DL-form [MI];Piperidine, 1-methyl-2-propyl-;NSC-363749;Piperidine, 1-methyl-2-propyl-, (+/-)-;starbld0035212;UNII-Z2XXC13FWM;SCHEMBL1760663;DTXSID901310152;NSC363749;NSC 363749;92701-56-9

Chemical Property of 1-Methyl-2-propylpiperidine

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 141.151749610
• Heavy Atom Count: 10
• Complexity: 90.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCC1CCCCN1C

Technology Process of 1-Methyl-2-propylpiperidine

There total 15 articles about 1-Methyl-2-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(1-methylpiperidin-2-yl)prop-1-yne (51498-57-8) → N-methylconiine (125133-94-0,553-75-3,92701-56-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 2.5h; under 760 Torr;

Reference yield:

rac-coniine (3238-60-6) + methyl iodide (74-88-4) → N-methylconiine (125133-94-0,553-75-3,92701-56-9)

Guidance literature:

In diethyl ether; at 60 ℃; for 24h; Inert atmosphere; Sealed tube;

Reference yield:

→ N-methylconiine (125133-94-0,553-75-3,92701-56-9)

Guidance literature:

With hydrogenchloride; amalgamated zinc;

DOI:10.1021/ja01177a044

upstream raw materials:

1-(1-methylpiperidin-2-yl)prop-1-yne

1-methylpiperidin-2-one

n-propylmagnesium bromide

hydrogenchloride

Downstream raw materials:

(+)-N-methylconiine

(-)-N-methylconiine

Refernces

• 1、 Takahata, Hiroki,Takahashi, Koichi,Wang, Eng-Chi,Yamazaki, Takao. "Alkynylation of Thiolactams. New Synthesis of α-Substituted Pyrrolidine and Piperidine Alkaloids". . p. 1211 - 1214. Retrieved 2007/10/02.
• 2、 Kitatsuji,Hirata,Yoshii,Iida. "Studies on the components in NTU shale oil. 3. The Hofmann degradation of alkylpiperidines". . p. 713 - 720. Retrieved 2007/10/04.