2-methyl-3-phenylpropanamide

Base Information

• Chemical Name: 2-methyl-3-phenylpropanamide
• CAS No.: 7499-19-6
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2924299090
• Mol file: 7499-19-6.mol

Synonyms:Hydrocinnamamide,a-methyl- (6CI);2-Methyl-3-phenylpropanamide; NSC 407544

Chemical Property of 2-methyl-3-phenylpropanamide

Chemical Property:

• Vapor Pressure: 8.55E-05mmHg at 25°C
• Boiling Point: 340.5°C at 760 mmHg
• Flash Point: 159.7°C
• PSA: 43.09000
• Density: 1.043g/cm³
• LogP: 2.05080

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-3-phenylpropanamide

There total 26 articles about 2-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

allylbenzene (300-57-2,57807-91-7) + carbon monoxide (201230-82-2) → 2-methyl-2-phenylpropionamide (7499-19-6)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; ammonium chloride; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 24h; under 22801.5 Torr; Autoclave;

Reference yield: 68.0%

methanol (67-56-1) + (2'S,5R)-1-(1'-oxo-2'-phenylmethylpropyl)-3,3,5-trimethylpyrrolidin-2-one (155956-28-8) → (S)-2-phenylmethylpropanamide (7499-19-6) + methyl (S)-(+)-2-benzylpropionate (38574-62-8)

Guidance literature:

With ammonia; at 0 ℃; for 2h;

DOI:10.1055/s-1998-1839

Reference yield: 60.0%

2-methyl-3-phenylpropanoic acid (1009-67-2) → 2-methyl-2-phenylpropionamide (7499-19-6)

Guidance literature:

2-methyl-3-phenylpropanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

With ammonium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

upstream raw materials:

α-methyl-β-phenylpropionitrile

2-methyl-3-phenylpropanoyl chloride

phenyl isopropyl ketone

ethyl 2-methyl-3-phenylpropionate

Downstream raw materials:

(S)-2-methyl-3-phenyl-propionitrile

2-methyl-3-phenylpropylamine

dexamfetamine

2-amino-1-phenylpropane

Refernces

• 1、 -. "Primary fatty acid amide preparation method". Paragraph 0157-0159. . Retrieved 2018/10/19.
• 2、 Colpaert, Filip,Mangelinckx, Sven,Verniest, Guido,De Kimpe, Norbert. "Asymmetric synthesis of α-alkylated N-sulfinyl imidates as new chiral building blocks". body text. p. 3792 - 3797. Retrieved 2009/09/29.