3-fluoro-α,α-dimethylbenzenebutanol

Base Information

• Chemical Name: 3-fluoro-α,α-dimethylbenzenebutanol
• CAS No.: 156868-21-2
• Molecular Formula: C₁₂H₁₇FO
• Molecular Weight: 196.265
• Mol file: 156868-21-2.mol

Synonyms:

Chemical Property of 3-fluoro-α,α-dimethylbenzenebutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-α,α-dimethylbenzenebutanol

There total 3 articles about 3-fluoro-α,α-dimethylbenzenebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(Bromomethyl)-3-fluorobenzene (456-41-7) → 3-fluoro-α,α-dimethylbenzenebutanol (156868-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Mg, 1,2-dibromoethane / 1.) ether, reflux, 1 h; 2.) ether, RT, 24 h

2: 55 percent / PBr₃, pyridine / benzene / 24 h / Ambient temperature

3: 1.) Mg, 1,2-dibromoethane / 1.) ether, reflux, 1 h; 2.) ether, RT, 24 h

With pyridine; phosphorus tribromide; magnesium; ethylene dibromide; In benzene;

DOI:10.1016/S0040-4020(01)87011-3

Reference yield:

3-(3-fluorophenyl)propan-1-ol (156868-83-6) → 3-fluoro-α,α-dimethylbenzenebutanol (156868-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / PBr₃, pyridine / benzene / 24 h / Ambient temperature

2: 1.) Mg, 1,2-dibromoethane / 1.) ether, reflux, 1 h; 2.) ether, RT, 24 h

With pyridine; phosphorus tribromide; magnesium; ethylene dibromide; In benzene;

DOI:10.1016/S0040-4020(01)87011-3

Reference yield:

1-(3-bromo-propyl)-3-fluoro-benzene (156868-84-7) + acetone (67-64-1) → 3-fluoro-α,α-dimethylbenzenebutanol (156868-21-2)

Guidance literature:

With magnesium; ethylene dibromide; Yield given. Multistep reaction; 1.) ether, reflux, 1 h; 2.) ether, RT, 24 h;

DOI:10.1016/S0040-4020(01)87011-3

upstream raw materials:

1-(3-bromo-propyl)-3-fluoro-benzene

acetone

1-(Bromomethyl)-3-fluorobenzene

3-(3-fluorophenyl)propan-1-ol