5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

Base Information

• Chemical Name: 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
• CAS No.: 1542066-79-4
• Molecular Formula: C₂₅H₂₄BrN₅O₂
• Molecular Weight: 506.402
• Mol file: 1542066-79-4.mol

Synonyms:

Chemical Property of 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

There total 5 articles about 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.1%

5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (1051871-37-4) → 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (1542066-79-4)

Guidance literature:

With potassium carbonate; In ethanol; for 8h; Reflux;

DOI:10.1021/jm401800k

Reference yield:

acetophenone (98-86-2) → 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (1542066-79-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 3 h / Reflux

2.1: 1,4-dioxane / 0.25 h

2.2: 12 h / 20 °C

3.1: hydrazine hydrate; acetic acid / 6.25 h / 0 °C / Reflux

4.1: potassium carbonate / ethanol / 8 h / Reflux

With sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; In 1,4-dioxane; methanol; ethanol;

DOI:10.1021/jm401800k

Reference yield:

2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester (41167-58-2) → 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(2-hydroxyethyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (1542066-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 0.25 h

1.2: 12 h / 20 °C

2.1: hydrazine hydrate; acetic acid / 6.25 h / 0 °C / Reflux

3.1: potassium carbonate / ethanol / 8 h / Reflux

With potassium carbonate; hydrazine hydrate; acetic acid; In 1,4-dioxane; ethanol;

DOI:10.1021/jm401800k

upstream raw materials:

acetophenone

2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester

4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one

5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one