C₆H₅C(OGe(CH₃)3)CH₂

Base Information

Chemical Name:C₆H₅C(OGe(CH₃)3)CH₂
CAS No.:41492-33-5
Molecular Formula:C₁₁H₁₆GeO
Molecular Weight:236.837
Hs Code.:

C<sub>6</sub>H<sub>5</sub>C(OGe(CH<sub>3</sub>)3)CH<sub>2</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₆H₅C(OGe(CH₃)3)CH₂

Chemical Property:

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Technology Process of C₆H₅C(OGe(CH₃)3)CH₂

There total 3 articles about C₆H₅C(OGe(CH₃)3)CH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1529-47-1
chlorotrimethylgermane

: 98-86-2
acetophenone

: 41492-37-9
C₆H₅C(O)CH₂Ge(CH₃)3

: 41492-33-5
C₆H₅C(OGe(CH₃)3)CH₂

Guidance literature:: With lithium diethylamide; In diethyl ether; to a soln. of i-Pr2NLi in Et2O was added a soln. of the ketone in Et2O at 0°C under N2, after 1 h ethereal Me3GeCl was added dropwise, mixt. was stirred for 2 h at 0°C and 3 h at room temp.; quenched with satd. aq. NH4Cl, extd. with Et2O, org. layer was washed with water, dried, concd., Me3Ge-ketone was isolated by Kugelrohr distn. (HRMS data); Me3Ge-ketone to enol ether ratio before hydrolysis 93 : 7 (GC-mass spectral and GLC data);
DOI:10.1021/om00155a019

Reference yield:

: 1529-47-1
chlorotrimethylgermane

: 98-86-2
acetophenone

: 4111-54-0
lithium diisopropyl amide

: 41492-37-9
C₆H₅C(O)CH₂Ge(CH₃)3

: 41492-33-5
C₆H₅C(OGe(CH₃)3)CH₂

Guidance literature:: In tetrahydrofuran; byproducts: LiCl; LiCl removal (centrifuge, N2 atmosphere); (1)H-NMR; product ratio PhC(OGeMe3)CH2/PhC(O)CH2GeMe3 9:91;
DOI:10.1039/c39880000802