N-hydroxy-4-methoxy-N-phenylbenzamide

Base Information

• Chemical Name: N-hydroxy-4-methoxy-N-phenylbenzamide
• CAS No.: 13664-49-8
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Hs Code.: 2924299090
• European Community (EC) Number: 633-075-9
• Nikkaji Number: J579.710A
• ChEMBL ID: CHEMBL1434553
• Mol file: 13664-49-8.mol

Synonyms:N-hydroxy-4-methoxy-N-phenylbenzamide;13664-49-8;4-METHOXY-N-PHENYLBENZOHYDROXAMIC ACID;ChemDiv2_000366;Oprea1_089460;CBDivE_001847;SCHEMBL837340;N-phenyl-p-anisohydroxamic acid;CHEMBL1434553;IMEJZBWBEXZVNP-UHFFFAOYSA-N;HMS1370A14;BBL028260;STK499924;AKOS001631448;NCGC00160218-01;VS-08706;CS-0316504;A925216;SR-01000408150;SR-01000408150-1

Chemical Property of N-hydroxy-4-methoxy-N-phenylbenzamide

Chemical Property:

• Vapor Pressure: 8.18E-08mmHg at 25°C
• Melting Point: 113 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 420.2oC at 760 mmHg
• PKA: 8.22±0.19(Predicted)
• Flash Point: 208oC
• PSA: 49.77000
• Density: 1.268g/cm3
• LogP: 2.73120
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 243.08954328
• Heavy Atom Count: 18
• Complexity: 268

Purity/Quality:

97% ^*data from raw suppliers

4-METHOXY-N-PHENYLBENZOHYDROXAMIC ACID Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)N(C2=CC=CC=C2)O

Technology Process of N-hydroxy-4-methoxy-N-phenylbenzamide

There total 6 articles about N-hydroxy-4-methoxy-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + Nitrosobenzene (586-96-9) → N-phenyl-p-methoxybenzohydroxamic acid (13664-49-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; In dichloromethane; at 20 ℃; for 0.166667 - 1h; Product distribution / selectivity;

Reference yield:

4,4'-dimethoxybenzoin (119-52-8) + Nitrosobenzene (586-96-9) → N-phenyl-p-methoxybenzohydroxamic acid (13664-49-8) + (R)-2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (119-52-8) + (S)-2-hydroxy-1,2-bis-(4-methoxyphenyl)ethan-1-one (119-52-8)

Guidance literature:

With benzaldehyde lyase; thiamine diphosphate; magnesium sulfate; In dichloromethane; at 30 ℃; for 96h; Reagent/catalyst; enantioselective reaction; Kinetics; Enzymatic reaction;

DOI:10.1002/adsc.201000735

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) + N-Phenylhydroxylamine (100-65-2) → N-phenyl-p-methoxybenzohydroxamic acid (13664-49-8)

Guidance literature:

With diethyl ether;

upstream raw materials:

4-methoxy-benzoyl chloride

N-Phenylhydroxylamine

nitrobenzene

4-methoxy-benzaldehyde

Downstream raw materials:

N-Phenylhydroxylamine

4-methoxybenzoic acid

Nitrosobenzene

MoO₂(ON(C₆H₅)CO(C₆H₄OCH₃))2