N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester
CAS No.:208987-32-0
Molecular Formula:C₆₄H₈₇N₅O₁₉
Molecular Weight:1230.42
Hs Code.:

N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

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Chemical Property of N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

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Technology Process of N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

There total 6 articles about N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4933-77-1
(3aR,5S,5aR,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-carbaldehyde

: 208987-32-0
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / bromotripyrrolidinophosphonium hexafluorophosphate, NMM / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) r.t., overnight

2: 93 percent / H₂O, NaOH / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

3: 53 percent / NMM, BOP, HOBT, molecular sieves 4 Angstroem / CH₂Cl₂

With 4-methyl-morpholine; sodium hydroxide; 4 A molecular sieve; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane;

Reference yield:

: 20866-48-2
(S)-2-(tert-butoxycarbonylamino)-3-(4-(tert-butoxycarbonyloxy)phenyl)propanoic acid

: 208987-32-0
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / BOP, HOBT, NMM, molecular sieves 4 Angstroem / CH₂Cl₂ / 36 h / Ambient temperature

2: 82 percent / NaOH, H₂O / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

3: 94 percent / bromotripyrrolidinophosphonium hexafluorophosphate, NMM / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) r.t., overnight

4: 93 percent / H₂O, NaOH / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

5: 53 percent / NMM, BOP, HOBT, molecular sieves 4 Angstroem / CH₂Cl₂

With 4-methyl-morpholine; sodium hydroxide; 4 A molecular sieve; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane;

Reference yield:

: 208987-24-0
N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine ethyl ester

: 208987-32-0
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-L-phenylalanyl-L-leucine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / BOP, HOBT, NMM, molecular sieves 4 Angstroem / CH₂Cl₂ / 36 h / Ambient temperature

2: 82 percent / NaOH, H₂O / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

3: 94 percent / bromotripyrrolidinophosphonium hexafluorophosphate, NMM / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) r.t., overnight

4: 93 percent / H₂O, NaOH / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

5: 53 percent / NMM, BOP, HOBT, molecular sieves 4 Angstroem / CH₂Cl₂

With 4-methyl-morpholine; sodium hydroxide; 4 A molecular sieve; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane;